ABSTRACT Introduction: Age-related Macular Degeneration (AMD), a retinal
neurodegenerative disease is the most common cause of blindness among the elderly in …

Abstract Melatonin (MT; N‑acetyl‑5‑methoxy‑tryptamine), which has multiple effects and
roles, is secreted from the pineal gland at night according to the daily rhythm. In addition to …

Melatonin is a hormone which is generated from pineal gland, and it is responsible for the
regulation of wake-sleep cycle. Melatonin is a well-known antioxidant and free radical …

Constant or intense light degenerates the retina and retinal pigment epithelial cells. Light
generates reactive oxygen species and nitric oxide leading to initial reactions of retinal …

Melatonin influences mammalian coat colour and hair follicle pigmentation and also weakly
alters the electrical stimulation of retinal cells in the eyes. A direct melanocytic response to …

The pineal hormone melatonin is a multi-functional molecule with a recognized role in
pigment aggregation in chromatophores, mediating its actions through binding to subtypes …

Purpose The current study aims to determine the molecular mechanisms of diabetic
retinopathy (DR) using the protein-protein interactome and metabolome map. We examined …

Disruption of the mitochondrial-nuclear network leads to accelerated aging and agerelated
diseases, including age-related macular degeneration. The current study tested the …

In the current study, we suggest that phosphorylation reactions of specific proteins in
mitochondria and the nucleus are a key step in the progression of age-related macular …

İÇİNDEKİLER IntroductIon Embryology of the eye Anatomy of the eye The hIstology of the
retIna 4.1. Blind spot 4.2. Blurred vision RetInal pIgment epIthelIum 5.1. Blood-retinal barrier …