Functions and properties of native peptides vary from highly specific antibiotics or cytotoxic
antitumor drugs, to hormones, neurotransmitters, immunomodulators, etc. Despite their …

Peptides have traditionally been perceived as poor drug candidates due to unfavorable
characteristics mainly regarding their pharmacokinetic behavior, including plasma stability …

Genetic code reprogramming is a method for the reassignment of arbitrary codons from
proteinogenic amino acids to nonproteinogenic ones; thus, specific sequences of …

Naturally occurring peptides often possess macrocyclic and N-methylated backbone. These
features grant them structural rigidity, high affinity to targets, proteolytic resistance, and …

Carboxylic acids are highly abundant in bioactive molecules. In this study, we describe the
late-stage β-C (sp3)–H deuteration of free carboxylic acids. On the basis of the finding that C …

The enzymatic β-C–H hydroxylation of the feedstock chemical isobutyric acid has enabled
the asymmetric synthesis of a wide variety of polyketides. The analogous transition metal …

Recent progress on the stereoselective synthesis of acyclic quaternary α-amino acids -
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Protein aggregation into cytotoxic oligomers and fibrils in vivo is linked to cell degeneration
and the pathogenesis of> 25 uncurable diseases, whereas the high aggregation propensity …

Peptides are a rapid-growing class of therapeutics with unique and desirable
physicochemical properties. Due to disadvantages such as low membrane permeability and …

Natural peptide products often contain N-methylated backbones, and such a modification
plays a crucial role in making natural peptides peptidase resistant and membrane …