Bone tissue is a highly vascularized tissue and concomitant development of the vascular
system and mineralized matrix requires a synergistic interaction between osteogenesis and …

Tissue engineering and regenerative medicine have shown potential in the repair and
regeneration of tissues and organs via the use of engineered biomaterials and scaffolds …

Background A considerable number of studies has been carried out to develop alloplastic
bone graft materials such as hydroxyapatite (HAP) that mimic the hierarchical structure of …

Adipose stem cells (ASCs) are a crucial element in bone tissue engineering (BTE). They are
easy to harvest and isolate, and they are available in significative quantities, thus offering a …

The development of functional scaffolds with improved osteogenic potential is important for
successful bone formation and mineralization in bone tissue engineering. In this study, we …

Despite the considerable advancements in fabricating polymeric-based scaffolds for tissue
engineering, the clinical transformation of these scaffolds remained a big challenge because …

Stem cells with mineralized materials have been used for bone regeneration; however,
engineering the complex vascularized structure of the natural bone remains a challenge …

The decellularized bone matrix (DCB) provides a promising bone substitute for the treatment
of bone defects because of its similar biochemical, biophysical, and mechanical properties …

Introduction: Cell-based therapies exploit the heterogeneous and self-sufficient biological
environment of stem cells to restore, maintain and improve tissue functions. Adipose-derived …

Adipose-derived stem cells (ADSCs) are considered to be ideal stem cell sources for bone
regeneration owing to their ability to differentiate into osteo-like cells. Therefore, they have …