The evolutionary pressure for life transitioning from extended periods of hypoxia to an
increasingly oxygenated atmosphere initiated drastic selections for a variety of biochemical …

Cell survival is conditional on the maintenance of a favourable acid–base balance (pH).
Owing to intensive respiratory CO2 and lactic acid production, cancer cells are exposed …

Intense interest in the'Warburg effect'has been revived by the discovery that hypoxia-
inducible factor 1 (HIF1) reprogrammes pyruvate oxidation to lactic acid conversion; lactic …

Na+/H+ exchangers play pivotal roles in the control of cell and tissue pH by mediating the
electroneutral exchange of Na+ and H+ across cellular membranes. They belong to an …

Tyrosine-specific protein kinase activity of the epidermal growth factor (EGF) receptor, pp60v-
src and pp110gag-fes was inhibited in vitro by an isoflavone genistein. The inhibition was …

Increased glucose consumption distinguishes cancer cells from normal cells and is known
as the" Warburg effect" because of increased glycolysis. Lactate dehydrogenase A (LDHA) …

Introduction• Intracellular pH regulation controls energy balance and cell proliferation:
chemical and biological proof of principle‐Chemical proof of principle‐Biological proof of …

Amiloride inhibits most plasma membrane Na+ transport systems. We have reviewed the
pharmacology of inhibition of these transporters by amiloride and its analogs. Thorough …

We have explored the hypothesis that contractile agonists are important regulators of
smooth muscle cell growth by examining the effects of one potent contractile agonist …

Precise spatiotemporal regulation of intracellular pH (pH i) is a prerequisite for normal cell
function, and changes in pH i or pericellular pH (pH e) exert important signalling functions. It …