Mendelian randomization

E Sanderson, MM Glymour, MV Holmes… - Nature Reviews …, 2022 - nature.com
Mendelian randomization (MR) is a term that applies to the use of genetic variation to
address causal questions about how modifiable exposures influence different outcomes …

Mendelian randomization: concepts and scope

RC Richmond, GD Smith - Cold Spring …, 2022 - perspectivesinmedicine.cshlp.org
Mendelian randomization (MR) is a method of studying the causal effects of modifiable
exposures (ie, potential risk factors) on health, social, and economic outcomes using genetic …

Strengthening the reporting of observational studies in epidemiology using mendelian randomisation (STROBE-MR): explanation and elaboration

VW Skrivankova, RC Richmond, BAR Woolf… - bmj, 2021 - bmj.com
Mendelian randomisation (MR) studies allow a better understanding of the causal effects of
modifiable exposures on health outcomes, but the published evidence is often hampered by …

Guidelines for performing Mendelian randomization investigations: update for summer 2023 [version 3; peer review: 2 approved]

S Burgess, G Davey Smith, NM Davies… - Wellcome open …, 2023 - discovery.ucl.ac.uk
This paper provides guidelines for performing Mendelian randomization investigations. It is
aimed at practitioners seeking to undertake analyses and write up their findings, and at …

Multivariable Mendelian randomization and mediation

E Sanderson - Cold Spring Harbor perspectives …, 2021 - perspectivesinmedicine.cshlp.org
Mendelian randomization (MR) is the use of genetic variants associated with an exposure to
estimate the causal effect of that exposure on an outcome. Mediation analysis is the method …

Evidence for causal effects of lifetime smoking on risk for depression and schizophrenia: a Mendelian randomisation study

RE Wootton, RC Richmond, BG Stuijfzand… - Psychological …, 2020 - cambridge.org
BackgroundSmoking prevalence is higher amongst individuals with schizophrenia and
depression compared with the general population. Mendelian randomisation (MR) can …

Methodological approaches, challenges, and opportunities in the application of Mendelian randomisation to lifecourse epidemiology: A systematic literature review

GM Power, E Sanderson, P Pagoni, A Fraser… - European journal of …, 2024 - Springer
Diseases diagnosed in adulthood may have antecedents throughout (including prenatal)
life. Gaining a better understanding of how exposures at different stages in the lifecourse …

Use of genetic variation to separate the effects of early and later life adiposity on disease risk: mendelian randomisation study

TG Richardson, E Sanderson, B Elsworth, K Tilling… - Bmj, 2020 - bmj.com
Objective To evaluate whether body size in early life has an independent effect on risk of
disease in later life or whether its influence is mediated by body size in adulthood. Design …

[图书][B] Mendelian randomization: methods for causal inference using genetic variants

S Burgess, SG Thompson - 2021 - books.google.com
Mendelian Randomization: Methods For Causal Inference Using Genetic Variants provides
thorough coverage of the methods and practical elements of Mendelian randomization …

Estimation of causal effects of a time-varying exposure at multiple time points through multivariable mendelian randomization

E Sanderson, TG Richardson, TT Morris, K Tilling… - PLoS …, 2022 - journals.plos.org
Mendelian Randomisation (MR) is a powerful tool in epidemiology that can be used to
estimate the causal effect of an exposure on an outcome in the presence of unobserved …