Substrate specificity controlled by the exit site of human P4-ATPases, revealed by de novo point mutations in neurological disorders
DC Calianese, T Noji, JA Sullivan, K Schoch… - Proceedings of the …, 2024 - pnas.org
The maintenance of lipid asymmetry on the plasma membrane is regulated by flippases,
such as ATP8A2, ATP11A, and ATP11C, which translocate phosphatidylserine and …
such as ATP8A2, ATP11A, and ATP11C, which translocate phosphatidylserine and …
Functional and in silico analysis of ATP8A2 and other P4-ATPase variants associated with human genetic diseases
E Matsell, JP Andersen… - Disease Models & …, 2024 - journals.biologists.com
ABSTRACT P4-ATPases flip lipids from the exoplasmic to cytoplasmic leaflet of cell
membranes, a property crucial for many biological processes. Mutations in P4-ATPases are …
membranes, a property crucial for many biological processes. Mutations in P4-ATPases are …
[HTML][HTML] Consensus, controversies, and conundrums of P4-ATPases: the emerging face of eukaryotic lipid flippases
The cryo-EM resolution revolution has heralded a new era in our understanding of
eukaryotic lipid flippases with a rapidly growing number of high-resolution structures …
eukaryotic lipid flippases with a rapidly growing number of high-resolution structures …
The danger of flipping an outside lipid to the inside
TR Graham - Proceedings of the National Academy of Sciences, 2024 - pnas.org
Cells fine-tune the composition and organization of the plasma membrane to ensure its
functional integrity. A complexity of membrane biogenesis is that the lipid composition of the …
functional integrity. A complexity of membrane biogenesis is that the lipid composition of the …
[HTML][HTML] Structural and functional properties of the N and C terminal segments of the P4-ATPase phospholipid flippase ATP8A2
E Matsell, M Mazaheri, JP Andersen… - Journal of Biological …, 2024 - Elsevier
Abstract ATP8A2 is a P4-ATPase that actively flips phosphatidylserine and to a lesser extent
phosphatidylethanolamine across cell membranes to generate and maintain …
phosphatidylethanolamine across cell membranes to generate and maintain …
[HTML][HTML] A novel missense variant in the ATPase domain of ATP8A2 and review of phenotypic variability of ATP8A2-related disorders caused by missense changes
KP Flannery, S Safwat, E Matsell, N Battula… - medRxiv, 2024 - ncbi.nlm.nih.gov
Abstract ATPase, class 1, type 8A, member 2 (ATP8A2) is a P4-ATPase with a critical role in
phospholipid translocation across the plasma membrane. Pathogenic variants in ATP8A2 …
phospholipid translocation across the plasma membrane. Pathogenic variants in ATP8A2 …
[HTML][HTML] Crossing the membrane—What does it take to flip a phospholipid? Structural and biochemical advances on P4-ATPase flippases
KV Sai, JYE Lee - Journal of Biological Chemistry, 2024 - Elsevier
Membrane asymmetry is critical for maintenance of several different processes such as cell
signaling, apoptosis, and vesicular transport in various eukaryotic systems. Flippases of the …
signaling, apoptosis, and vesicular transport in various eukaryotic systems. Flippases of the …