Hypertension is both a cause and a consequence of central artery stiffening, which in turn is
an initiator and indicator of myriad disease conditions and thus all-cause mortality. Such …

Arteries exhibit a remarkable ability to adapt to diverse genetic defects and sustained
alterations in mechanical loading. For example, changes in blood flow induced wall shear …

The stiffness and structural integrity of the arterial wall depends primarily on the organization
of the extracellular matrix and the cells that fashion and maintain this matrix. Fundamental to …

Through mechanobiological control of the extracellular matrix, and hence local stiffness,
smooth muscle cells of the media and fibroblasts of the adventitia play important roles in …

This review discusses sexual dimorphism in arterial stiffening, disease pathology
interactions, and the influence of sex on mechanisms and pathways. Arterial stiffness …

The embryonic lineage of intramural cells, microstructural organization of the extracellular
matrix, local luminal and wall geometry, and haemodynamic loads vary along the length of …

There has been a growing awareness over the past decade that stiffening of the aorta, and
its attendant effects on hemodynamics, is both an indicator and initiator of diverse …

The American Heart Association makes every effort to avoid any actual or potential conflicts
of interest that may arise as a result of an outside relationship or a personal, professional, or …

The primary function of central arteries is to store elastic energy during systole and to use it
to sustain blood flow during diastole. Arterial stiffening compromises this normal mechanical …

Hypertension induces significant aortic remodelling, often adaptive but sometimes not. To
identify immuno-mechanical mechanisms responsible for differential remodelling, we …