[HTML][HTML] Angiogenesis in breast cancer progression, diagnosis, and treatment

CO Madu, S Wang, CO Madu, Y Lu - Journal of Cancer, 2020 - ncbi.nlm.nih.gov
Angiogenesis is a significant event in a wide range of healthy and diseased conditions. This
process frequently involves vasodilation and an increase in vascular permeability …

Targeting angiogenesis in cancer therapy: moving beyond vascular endothelial growth factor

Y Zhao, AA Adjei - The oncologist, 2015 - academic.oup.com
Angiogenesis, or the formation of new capillary blood vessels, occurs primarily during
human development and reproduction; however, aberrant regulation of angiogenesis is also …

Prospective multicenter cohort study to refine management recommendations for women at elevated familial risk of breast cancer: the EVA trial

C Kuhl, S Weigel, S Schrading, B Arand… - Journal of Clinical …, 2010 - ascopubs.org
Purpose We investigated the respective contribution (in terms of cancer yield and stage at
diagnosis) of clinical breast examination (CBE), mammography, ultrasound, and quality …

Exploration of novel VEGFR2 tyrosine kinase inhibitors via design and synthesis of new alkylated indolyl-triazole Schiff bases for targeting breast cancer

MS Nafie, ATA Boraei - Bioorganic Chemistry, 2022 - Elsevier
Abstract According to the World Health Organization (WHO) statistics: In 2020, there were
2.3 million women diagnosed with breast cancer and 685,000 deaths globally. Therefore …

Nonclinical antiangiogenesis and antitumor activities of axitinib (AG-013736), an oral, potent, and selective inhibitor of vascular endothelial growth factor receptor …

DD Hu-Lowe, HY Zou, ML Grazzini, ME Hallin… - Clinical Cancer …, 2008 - AACR
Abstract Purpose: Axitinib (AG-013736) is a potent and selective inhibitor of vascular
endothelial growth factor (VEGF) receptor tyrosine kinases 1 to 3 that is in clinical …

Stepping out of the flow: capillary extravasation in cancer metastasis

FL Miles, FL Pruitt, KL Van Golen… - Clinical & experimental …, 2008 - Springer
In order for cancer cells to successfully colonize a metastatic site, they must detach from the
primary tumor using extracellular matrix-degrading proteases, intravasate and survive in the …

Three-dimensional in vitro cancer models: a short review

C Wang, Z Tang, Y Zhao, R Yao, L Li, W Sun - Biofabrication, 2014 - iopscience.iop.org
The re-creation of the tumor microenvironment including tumor–stromal interactions, cell–
cell adhesion and cellular signaling is essential in cancer-related studies. Traditional two …

Oncolytic virus encoding a master pro-inflammatory cytokine interleukin 12 in cancer immunotherapy

HM Nguyen, K Guz-Montgomery, D Saha - Cells, 2020 - mdpi.com
Oncolytic viruses (OVs) are genetically modified or naturally occurring viruses, which
preferentially replicate in and kill cancer cells while sparing healthy cells, and induce anti …

Monophosphine Ligands Promote Pd-Catalyzed C–S Cross-Coupling Reactions at Room Temperature with Soluble Bases

J Xu, RY Liu, CS Yeung, SL Buchwald - ACS catalysis, 2019 - ACS Publications
The Pd-catalyzed cross-coupling of thiols with aromatic electrophiles is a reliable method for
the synthesis of aryl thioethers, which are important compounds for pharmaceutical and …

Clinical pharmacology of axitinib

Y Chen, MA Tortorici, M Garrett, B Hee… - Clinical …, 2013 - Springer
Axitinib is a potent and selective second-generation inhibitor of vascular endothelial growth
factor receptors 1, 2, and 3 that is approved in the US and several other countries for …