Benefits and limitations of genome-wide association studies
Genome-wide association studies (GWAS) involve testing genetic variants across the
genomes of many individuals to identify genotype–phenotype associations. GWAS have …
genomes of many individuals to identify genotype–phenotype associations. GWAS have …
[HTML][HTML] Aqueous outflow-A continuum from trabecular meshwork to episcleral veins
T Carreon, E van der Merwe, RL Fellman… - Progress in retinal and …, 2017 - Elsevier
In glaucoma, lowered intraocular pressure (IOP) confers neuroprotection. Elevated IOP
characterizes glaucoma and arises from impaired aqueous humor (AH) outflow. Increased …
characterizes glaucoma and arises from impaired aqueous humor (AH) outflow. Increased …
Meta-analysis of 542,934 subjects of European ancestry identifies new genes and mechanisms predisposing to refractive error and myopia
Refractive errors, in particular myopia, are a leading cause of morbidity and disability
worldwide. Genetic investigation can improve understanding of the molecular mechanisms …
worldwide. Genetic investigation can improve understanding of the molecular mechanisms …
Single-cell analysis of human retina identifies evolutionarily conserved and species-specific mechanisms controlling development
The development of single-cell RNA sequencing (scRNA-seq) has allowed high-resolution
analysis of cell-type diversity and transcriptional networks controlling cell-fate specification …
analysis of cell-type diversity and transcriptional networks controlling cell-fate specification …
Extracellular matrix in the trabecular meshwork: intraocular pressure regulation and dysregulation in glaucoma
The trabecular meshwork (TM) is located in the anterior segment of the eye and is
responsible for regulating the outflow of aqueous humor. Increased resistance to aqueous …
responsible for regulating the outflow of aqueous humor. Increased resistance to aqueous …
The rationale for targeting the LOX family in cancer
The therapeutic targeting of extracellular proteins is becoming hugely attractive in light of
evidence implicating the tumour microenvironment as pivotal in all aspects of tumour …
evidence implicating the tumour microenvironment as pivotal in all aspects of tumour …
Genetic mapping in human disease
D Altshuler, MJ Daly, ES Lander - science, 2008 - science.org
Genetic mapping provides a powerful approach to identify genes and biological processes
underlying any trait influenced by inheritance, including human diseases. We discuss the …
underlying any trait influenced by inheritance, including human diseases. We discuss the …
Human genetic variation and its contribution to complex traits
The last few years have seen extensive efforts to catalogue human genetic variation and
correlate it with phenotypic differences. Most common SNPs have now been assessed in …
correlate it with phenotypic differences. Most common SNPs have now been assessed in …
How to interpret a genome-wide association study
TA Pearson, TA Manolio - Jama, 2008 - jamanetwork.com
Genome-wide association (GWA) studies use high-throughput genotyping technologies to
assay hundreds of thousands of single-nucleotide polymorphisms (SNPs) and relate them to …
assay hundreds of thousands of single-nucleotide polymorphisms (SNPs) and relate them to …
Anatomy and organization of human skin
JA McGrath, RAJ Eady, FM Pope - Rook's textbook of …, 2004 - books.google.com
Human skin consists of a stratified, cellular epidermis and an underlying dermis of
connective tissue [1–5]. The dermal–epidermal junction is undulating in section; ridges of …
connective tissue [1–5]. The dermal–epidermal junction is undulating in section; ridges of …