Colorectal cancer (CRC) develops from polyps in the inner large intestine or rectum and an
increasing incidence and high mortality rate has been observed in humans. Currently …

Colorectal cancer (CRC) is one of the leading causes of cancer-related deaths. Therefore,
more sensitive and early diagnostic methods for CRC are urgently needed. In this study, an …

Myristoylation occurs cotranslationally on nascent proteins and post‐translationally during
apoptosis after caspase cleavages expose cryptic myristoylation sites. We demonstrate a …

The lipidic modification of proteins has recently been shown to be of immense importance,
although many of the roles of these modifications remain as yet unidentified. One of such …

Lipid transferase-catalyzed protein lipidation plays critical roles in many physiological
processes and it has been an increasingly attractive therapeutic target from cancer to …

The intrinsic fluorescence of synthetic or natural porphyrins is regarded as an attractive
characteristic exploited for assisting early cancer diagnosis and/or tumor localization. Single …

N-myristoylation is the irreversible attachment of myristate, a C14-lipid, to the N-terminal
glycine of a protein. This modification is catalysed by myristoyl CoA: protein N …

SIRT2 AND NMT INHIBITION SUPPRESS COLON CANCER THROUGH ARF6 LYSINE
MYRISTOYLATION Page 108 94 CHAPTER 3 SIRT2 AND NMT INHIBITION SUPPRESS …

Decades of work on N-terminal myristylation have generated munch knowledge about the
basic rules that govern the addition of this modification to protein substrates by the N …

N-myristoyltransferases (NMTs) are ubiquitous among eukaryotes and are widely known for
adding a myristoyl, saturated 14-carbon chain, to the amino group of the N-terminal glycine …