Designer exosomes: a new platform for biotechnology therapeutics

D Jafari, S Shajari, R Jafari, N Mardi, H Gomari, F Ganji… - BioDrugs, 2020 - Springer
Desirable features of exosomes have made them a suitable manipulative platform for
biomedical applications, including targeted drug delivery, gene therapy, cancer diagnosis …

Paracrine mechanisms of mesenchymal stromal cells in angiogenesis

S Maacha, H Sidahmed, S Jacob… - Stem cells …, 2020 - Wiley Online Library
The role of the mesenchymal stromal cell‐(MSC‐) derived secretome is becoming
increasingly intriguing from a clinical perspective due to its ability to stimulate endogenous …

Mesenchymal stem cell-derived extracellular vesicles affect disease outcomes via transfer of microRNAs

G Qiu, G Zheng, M Ge, J Wang, R Huang… - Stem Cell Research & …, 2018 - Springer
Mesenchymal stem cells (MSCs) are adult stromal cells with the capacity to differentiate into
multiple types of cells. MSCs represent an attractive option in regenerative medicine due to …

Immunomodulatory effects of mesenchymal stem cells and mesenchymal stem cell-derived extracellular vesicles in rheumatoid arthritis

H Liu, R Li, T Liu, L Yang, G Yin, Q Xie - Frontiers in Immunology, 2020 - frontiersin.org
Rheumatoid arthritis (RA) is a chronic autoimmune disease that affects the joints and other
organs for which there is currently no effective treatment. Mesenchymal stem cells (MSCs) …

Functional proteins of mesenchymal stem cell-derived extracellular vesicles

G Qiu, G Zheng, M Ge, J Wang, R Huang… - Stem cell research & …, 2019 - Springer
Extracellular vesicles (EVs) contain proteins, microRNAs, mRNAs, long non-coding RNAs,
and phospholipids, and are a novel mechanism of intercellular communication. It has been …

Sorting and packaging of RNA into extracellular vesicles shape intracellular transcript levels

T O'Grady, MS Njock, M Lion, J Bruyr, E Mariavelle… - BMC biology, 2022 - Springer
Abstract Background Extracellular vesicles (EVs) are released by nearly every cell type and
have attracted much attention for their ability to transfer protein and diverse RNA species …

[HTML][HTML] Mesenchymal stem cell-derived exosomes as drug delivery vehicles in disease therapy

W Zhao, K Li, L Li, R Wang, Y Lei, H Yang… - International Journal of …, 2024 - mdpi.com
Exosomes are small vesicles containing proteins, nucleic acids, and biological lipids, which
are responsible for intercellular communication. Studies have shown that exosomes can be …

Extracellular vesicles: Interplay with the extracellular matrix and modulated cell responses

A Al Halawani, SM Mithieux, GC Yeo… - International journal of …, 2022 - mdpi.com
The discovery that cells secrete extracellular vesicles (EVs), which carry a variety of
regulatory proteins, nucleic acids, and lipids, has shed light on the sophisticated manner by …

[HTML][HTML] Mesenchymal stem cell exosomes in bone regenerative strategies—a systematic review of preclinical studies

SHS Tan, JRY Wong, SJY Sim, CKE Tjio, KL Wong… - Materials Today Bio, 2020 - Elsevier
The ability of bone for regeneration has long been recognized. However, once beyond a
critical size, spontaneous regeneration of bone is limited. Several studies have focused on …

Angiogenic effects and crosstalk of adipose-derived mesenchymal stem/stromal cells and their extracellular vesicles with endothelial cells

S Rautiainen, T Laaksonen, R Koivuniemi - International Journal of …, 2021 - mdpi.com
Adipose-derived mesenchymal stem/stromal cells (ASCs) are an adult stem cell population
able to self-renew and differentiate into numerous cell lineages. ASCs provide a promising …