Genomic instability and mutations underlie the hallmarks of cancer—genetic alterations
determine cancer cell fate by affecting cell proliferation, apoptosis and immune response …

As key regulators of cytoskeletal dynamics, Rho GTPases coordinate a wide range of
cellular processes, including cell polarity, cell migration, and cell cycle progression. The …

ROCK belongs to the AGC family of Ser/Thr protein kinases that are involved in many
cellular processes. ROCK-driven actomyosin contractility regulates cytoskeletal dynamics …

The Rho‐associated (ROCK) serine/threonine kinases have emerged as central regulators
of the actomyosin cytoskeleton, their main purpose being to promote contractile force …

Rho-associated coiled-coil kinase (ROCK) is a major downstream effector of the small
GTPase RhoA. The ROCK family, consisting of ROCK1 and ROCK2, plays a central role in …

Rho-associated kinases ROCK1 and ROCK2 are key regulators of actin cytoskeleton
dynamics downstream of Rho GTPases that participate in the control of important …

The group of AGC protein kinases includes more than 60 protein kinases in the human
genome, classified into 14 families: PDK1, AKT/PKB, SGK, PKA, PKG, PKC, PKN/PRK, RSK …

Protein kinases orchestrate the activation of signaling cascades in response to extracellular
and intracellular stimuli to control cell growth, proliferation, and survival. The complexity of …

Abstract The Ser/Thr Rho kinase 1 (ROCK1) is known to have major roles in a wide range of
cellular activities, including those involved in tumour metastasis and apoptosis. Here we …

Rho-associated coiled-coil-containing protein kinase (ROCK)/Lin11, Isl-1 and Mec-3 kinase
(LIMK)/cofilin-signaling cascades are stimulated by receptor tyrosine kinases, G protein …