Age-associated neurological diseases represent a profound challenge in biomedical
research as we are still struggling to understand the interface between the aging process …

During the past two decades, induced pluripotent stem cells (iPSCs) have been widely used
to study mechanisms of human neural development, disease modeling, and drug discovery …

Direct reprogramming of somatic cells into induced pluripotent stem cells (iPSCs) provides a
unique opportunity to derive patient-specific stem cells with potential applications in tissue …

Objective—Stem cell therapy for angiogenesis and vascular regeneration has been
investigated using adult or embryonic stem cells. In the present study, we investigated the …

The ability to reprogram adult somatic cells back to pluripotency presents a powerful tool for
studying cell-fate identity and modeling human disease. However, the reversal of cellular …

Background As stem cells of the early embryo mature and differentiate into all tissues, the
mitochondrial complement undergoes dramatic functional improvement. Mitochondrial …

Aging is accompanied by the functional decline of cells, tissues, and organs, as well as a
striking increase in a wide range of diseases. The reprogramming of somatic cells to …

Age-related macular degeneration (AMD) is one of the major causes of blindness in aging
population that progresses with death of retinal pigment epithelium (RPE) and photoreceptor …

Over the past decade, there has been a dramatic increase in efforts to ameliorate aging and
the diseases it causes, with transient expression of nuclear reprogramming factors recently …

Pluripotent stem cells (PSCs) must maintain their proper genomic content in order to
preserve appropriate self-renewal and differentiation capacities. However, their prolonged in …