Antisense oligonucleotides restore excitability, GABA signalling and sodium current density in a Dravet syndrome model
Y Yuan, L Lopez-Santiago, N Denomme, C Chen… - Brain, 2024 - academic.oup.com
Dravet syndrome is an intractable developmental and epileptic encephalopathy caused by
de novo variants in SCN1A resulting in haploinsufficiency of the voltage-gated sodium …
de novo variants in SCN1A resulting in haploinsufficiency of the voltage-gated sodium …
New focus on cardiac voltage-gated sodium channel β1 and β1B: Novel targets for treating and understanding arrhythmias?
ZJ Williams, LB Payne, X Wu, RG Gourdie - Heart Rhythm, 2024 - Elsevier
Voltage-gated sodium channels (VGSCs) are transmembrane protein complexes that are
vital to the generation and propagation of action potentials in nerve and muscle fibers. The …
vital to the generation and propagation of action potentials in nerve and muscle fibers. The …
Decreased ability to manage increases in reactive oxygen species may underlie susceptibility to arrhythmias in mice lacking Scn1b
JL Aldridge, ED Alexander… - American Journal of …, 2024 - journals.physiology.org
Scn1b plays essential roles in the heart, where it encodes β1-subunits that serve as
modifiers of gene expression, cell surface channel activity, and cardiac conductivity …
modifiers of gene expression, cell surface channel activity, and cardiac conductivity …
Graph attention automatic encoder based on contrastive learning for domain recognition of spatial transcriptomics
T Wang, H Zhu, Y Zhou, W Ding, W Ding, L Han… - Communications …, 2024 - nature.com
Spatial transcriptomics is an emerging technology that enables the profiling of gene
expression in tissues while preserving spatial location information. This innovative approach …
expression in tissues while preserving spatial location information. This innovative approach …
[PDF][PDF] Brain Communications 2023 early career researcher paper prize
TL Spires-Jones - Brain Communications, 2024 - academic.oup.com
BRAIN COMMUNICATIONS Page 1 EDITORIAL Brain Communications 2023 early career
researcher paper prize Graphical Abstract Welcome to Volume 6, issue 1 of Brain …
researcher paper prize Graphical Abstract Welcome to Volume 6, issue 1 of Brain …
LOF 1B or not LOF 1B, That is the Question: Insights From a New Mouse Model of SCN1B DEE
JL Wagnon - Epilepsy Currents, 2024 - journals.sagepub.com
Epilepsy and sudden unexpected death in epilepsy in a mouse model of human SCN1B-
linked developmental and epileptic encephalopathy. Chen C, Ziobro J, Robinson-Cooper L …
linked developmental and epileptic encephalopathy. Chen C, Ziobro J, Robinson-Cooper L …