Developmental and epileptic encephalopathies (DEEs) are a heterogeneous group of
disorders characterized by early-onset, often severe epileptic seizures and EEG …

The nodes of Ranvier have clustered Na+ and K+ channels necessary for rapid and efficient
axonal action potential conduction. However, detailed mechanisms of channel clustering …

Acute and chronic pain complaints, although common, are generally poorly served by
existing therapies. This unmet clinical need reflects a failure to develop novel classes of …

Developmental encephalopathies, including intellectual disability and autistic spectrum
disorder, are frequently associated with infant epilepsy. Epileptic encephalopathy is used to …

At the base of axons sits a unique compartment called the axon initial segment (AIS). The
AIS generates and shapes the action potential before it is propagated along the axon …

Innocuous touch of the skin is detected by distinct populations of neurons, the low-threshold
mechanoreceptors (LTMRs), which are classified as Aβ-, Aδ-, and C-LTMRs. Here, we report …

Axons are generally considered as reliable transmission cables in which stable propagation
occurs once an action potential is generated. Axon dysfunction occupies a central position in …

The axon initial segment (AIS) is a specialized membrane region in the axon of neurons
where action potentials are initiated. Crucial to the function of the AIS is the presence of …

Loss-of-function mutations in human SCN1A gene encoding Nav1. 1 are associated with a
severe epileptic disorder known as severe myoclonic epilepsy in infancy. Here, we …

KCNQ genes encode five Kv7 K+ channel subunits (Kv7. 1–Kv7. 5). Four of these (Kv7. 2–
Kv7. 5) are expressed in the nervous system. Kv7. 2 and Kv7. 3 are the principal molecular …