Gangliosides are glycosphingolipids highly abundant in the nervous system, and carry most
of the sialic acid residues in the brain. Gangliosides are enriched in cell membrane …

Lipids have many important biological roles, such as energy storage sources, structural
components of plasma membranes and as intermediates in metabolic and signaling …

Abstract Metabolism of MPTP (1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine) to the
neurotoxin MPP+ in the brain causes permanent Parkinson's disease-like symptoms by …

There is emerging evidence that amyloid beta (Aβ) aggregates forming neuritic plaques lead
to impairment of the lipid‐rich myelin sheath and glia. In this study, we examined focal …

Alzheimer's disease (AD) is associated with progressive accumulation of amyloid-β (Aβ)
cross-β fibrils in the brain. Aβ species tightly associated with GM1 ganglioside, a …

Ganglioside GM1 is the most common brain ganglioside enriched in plasma membrane
regions known as lipid rafts or membrane microdomains. GM1 participates in many …

Revealing the metabolic abnormalities of central and peripheral systems in Alzheimer's
disease (AD) mouse model is of paramount importance for understanding AD disease …

Cluster ion beam ToF-SIMS and/or MALDI-ToF mass spectrometry imaging (using 1, 5-DAN
matrix via sublimation) of a single coronal rat brain tissue section followed by classical-or …

Several techniques are currently being developed for spatially resolved omics profiling, but
each new method requires the setup of specific detection strategies or specialized …

Mass spectrometry imaging (MSI) is a powerful technique that combines the ability of
microscopy to provide spatial information about multiple molecular species with the …