Conserved and divergent mechanisms of inner kinetochore assembly onto centromeric chromatin
Kinetochores are large protein complexes built on centromeric chromatin that mediate
chromosome segregation. The inner kinetochore, or constitutive centromere-associated …
chromosome segregation. The inner kinetochore, or constitutive centromere-associated …
[HTML][HTML] Histone variants and chromatin structure, update of advances
Histone proteins are highly conserved among all eukaryotes. They have two important
functions in the cell: to package the genomic DNA and to regulate gene accessibility …
functions in the cell: to package the genomic DNA and to regulate gene accessibility …
Cryo-EM structure of the complete inner kinetochore of the budding yeast point centromere
The point centromere of budding yeast specifies assembly of the large kinetochore complex
to mediate chromatid segregation. Kinetochores comprise the centromere-associated inner …
to mediate chromatid segregation. Kinetochores comprise the centromere-associated inner …
Phase-plate cryo-EM structure of the Widom 601 CENP-A nucleosome core particle reveals differential flexibility of the DNA ends
The histone H3 variant CENP-A marks centromeres epigenetically and is essential for
mitotic fidelity. Previous crystallographic studies of the CENP-A nucleosome core particle …
mitotic fidelity. Previous crystallographic studies of the CENP-A nucleosome core particle …
[HTML][HTML] Recent advances in single-molecule fluorescence microscopy render structural biology dynamic
Highlights•Single-molecule fluorescence microscopy is a powerful tool to study the structural
dynamics of biological macromolecules.•Recent developments in multi-coordinate single …
dynamics of biological macromolecules.•Recent developments in multi-coordinate single …
Are extraordinary nucleosome structures more ordinary than we thought?
CYY Chong, L Gan - Chromosoma, 2023 - Springer
The nucleosome is a DNA–protein assembly that is the basic unit of chromatin. A
nucleosome can adopt various structures. In the canonical nucleosome structure, 145–147 …
nucleosome can adopt various structures. In the canonical nucleosome structure, 145–147 …
Structural insights into p300 regulation and acetylation-dependent genome organisation
Z Ibrahim, T Wang, O Destaing, N Salvi… - Nature …, 2022 - nature.com
Histone modifications are deposited by chromatin modifying enzymes and read out by
proteins that recognize the modified state. BRD4-NUT is an oncogenic fusion protein of the …
proteins that recognize the modified state. BRD4-NUT is an oncogenic fusion protein of the …
Structural and dynamic mechanisms of CBF3-guided centromeric nucleosome formation
Accurate chromosome segregation relies on the specific centromeric nucleosome–
kinetochore interface. In budding yeast, the centromere CBF3 complex guides the …
kinetochore interface. In budding yeast, the centromere CBF3 complex guides the …
CENP-A nucleosome—a chromatin-embedded pedestal for the centromere: lessons learned from structural biology
A Ali-Ahmad, N Sekulić - Essays in Biochemistry, 2020 - portlandpress.com
The centromere is a chromosome locus that directs equal segregation of chromosomes
during cell division. A nucleosome containing the histone H3 variant CENP-A epigenetically …
during cell division. A nucleosome containing the histone H3 variant CENP-A epigenetically …
Methylation of CENP-A/Cse4 on arginine 143 and lysine 131 regulates kinetochore stability in yeast
TM Tran Nguyen, A Munhoven… - Genetics, 2023 - academic.oup.com
Post-translational modifications on histones are well known to regulate chromatin structure
and function, but much less information is available on modifications of the centromeric …
and function, but much less information is available on modifications of the centromeric …