Ferroptosis is a type of cell death that depends on iron and reactive oxygen species (ROS).
The accumulation of iron and lipid peroxidation primarily initiates oxidative membrane …

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer death worldwide.
HCC progression and metastasis are closely related to altered mitochondrial metabolism …

Ferroptosis is a type of iron-dependent regulated cell death, representing an emerging
disease-modulatory mechanism. Transcription factors play multiple roles in ferroptosis …

Oral squamous cell carcinoma (OSCC) is the most common type of oral malignancy, and
metastasis accounts for the poor prognosis of OSCC. Autophagy is considered to facilitate …

Type I and III interferons (IFNs) activate similar downstream signaling cascades, but unlike
type I IFNs, type III IFNs (IFNλ) do not elicit strong inflammatory responses in vivo. Here, we …

Intrinsically disordered proteins (IDPs) do not have a well-defined structure under
physiological conditions, but they have key roles in cell signaling and regulation, and they …

Ferroptosis is an iron-dependent cell death characterized by the accumulation of
hydroperoxided phospholipids. Here, we report that the NUPR1 inhibitor ZZW-115 induces …

Rationale: Hepatocellular carcinoma (HCC) is a highly heterogeneous and malignant
disease with the complex immune microenvironment, which ultimately influence clinic …

Intrinsically disordered proteins (IDPs) are emerging as attractive drug targets by virtue of
their prevalence in various diseases including cancer. Drug development targeting IDPs is …

Approximately 90% of pancreatic cancers are pancreatic ductal adenocarcinomas (PDAC).
PDAC is the fourth leading cause of cancer death world-wide. Therapies for PDAC are …