Metastasis is the leading cause of cancer-associated mortality and the underlying
mechanisms of cancer metastasis remain elusive. Both blood and lymphatic vasculatures …

Extensive research during the past 2 decades has revealed the mechanism by which
continued oxidative stress can lead to chronic inflammation, which in turn could mediate …

Activating mutations in KRAS occur in 30% to 40% of colorectal cancers. How mutant KRAS
alters cancer cell behavior has been studied intensively, but non-cell autonomous effects of …

The formation of the vascular network is an intricate and complex process that is an obligate
requirement during vertebrate development. The cardiovascular system is the first organ to …

It has been known for many years that cellular metabolism within the solid tumour is
markedly different from that of the corresponding normal tissue. The transcription factor …

Biology of Vascular Endothelial Growth Factor | Endocrine Reviews | Oxford Academic Skip to
Main Content Advertisement Oxford Academic Journals Books Search Menu Information …

Hypoxia and free radicals, such as reactive oxygen and nitrogen species, can alter the
function and/or activity of the transcription factor hypoxia-inducible factor 1 (HIF1). Interplay …

Oncogenic transformation and hypoxia both induceglut1 mRNA. We studied the interaction
between theras oncogene and hypoxia in up-regulating glut1mRNA levels using Rat1 …

Over seven decades ago, classical biochemical studies showed that tumors have altered
metabolic profiles and display high rates of glucose uptake and glycolysis. Although these …

Vascular endothelial growth factor (VEGF) is a secreted mitogen highly specific for cultured
endothelial cells. In vivo VEGF induces microvascular permeability and plays a central role …