The incidence of invasive pneumococcal disease (IPD) caused by infection with the
pathogen Streptococcus pneumoniae (Spn) has been on a downward trend for decades due …

The surface of cells is coated with a dense layer of glycans, known as the cell glycocalyx.
The complex glycans in the glycocalyx are involved in various biological events, such as …

Rheumatoid arthritis (RA) involves several classes of pathogenic autoantibodies, some of
which react with type-II collagen (COL2) in articular cartilage. We previously described a …

Glycoconjugate vaccines are among the most effective interventions for preventing several
serious infectious diseases. Covalent linkage of the bacterial capsular polysaccharide to a …

Carbohydrates as T cell-activating antigens have been generating significant interest. For
many years, carbohydrates were thought of as T-independent antigens, however, more …

Streptococcus pneumoniae is an opportunistic pathogen that causes over 1 million deaths
annually despite the availability of several multivalent pneumococcal conjugate vaccines …

Glycosylation is arguably the most ubiquitous post-translational modification on proteins in
microbial and mammalian cells. During the past few years, there has been intensive …

Abstract Group B Streptococcus (GBS) is a major cause of morbidity and mortality among
neonates. Though there have been tremendous advances in prevention of invasive …

A single-nucleotide polymorphism of neutrophil cytosolic factor 1 (Ncf1), leading to an
impaired generation of reactive oxygen species (ROS), is a causative genetic factor for …

Carbohydrates are ubiquitous molecules expressed on the surface of nearly all living cells,
and their interaction with carbohydrate-binding proteins is critical to many immunobiological …