Considerable advances in our understanding of the mechanisms and functions of rapid-eye-
movement (REM) sleep have occurred over the past decade. Much of this progress can be …

Sleep is highly conserved across evolution, suggesting vital biological functions that are yet
to be fully understood. Animals and humans experiencing partial sleep restriction usually …

The sleep-wake cycle regulates interstitial fluid (ISF) and cerebrospinal fluid (CSF) levels of
β-amyloid (Aβ) that accumulates in Alzheimer's disease (AD). Furthermore, chronic sleep …

Adult hippocampal neurogenesis plays a critical role in memory and emotion processing,
and this process is dynamically regulated by neural circuit activity. However, it remains …

The ability to recognize information that is incongruous with previous experience is critical
for survival. Novelty signals have therefore evolved in the mammalian brain to enhance …

Brain activity during sleep is characterized by circuit-specific oscillations, including slow
waves, spindles and theta waves, which are nested in thalamocortical or hippocampal …

Neurons in the mammalian brain are not limited to releasing a single neurotransmitter but
often release multiple neurotransmitters onto postsynaptic cells. Here, we review recent …

We screened for novel circuits in the mouse brain that promote wakefulness. Chemogenetic
activation experiments and electroencephalogram recordings pointed to …

The cerebellar vermis, long associated with axial motor control, has been implicated in a
surprising range of neuropsychiatric disorders and cognitive and affective functions …

Patients with Alzheimer's disease (AD) exhibit progressive memory loss, depression, and
anxiety, accompanied by impaired adult hippocampal neurogenesis (AHN). Whether AHN …