Ferroptosis: machinery and regulation

X Chen, J Li, R Kang, DJ Klionsky, D Tang - Autophagy, 2021 - Taylor & Francis
Ferroptosis is an iron-dependent, non-apoptotic form of regulated cell death caused by lipid
peroxidation, which is controlled by integrated oxidation and antioxidant systems. The iron …

The application of ferroptosis in diseases

Y Qiu, Y Cao, W Cao, Y Jia, N Lu - Pharmacological Research, 2020 - Elsevier
Ferroptosis is a new kind of regulated cell death that is characterized by highly iron-
dependent lipid peroxidation. Ferroptosis involves various biology processes, such as iron …

Ferroptosis as a mechanism of non-ferrous metal toxicity

M Aschner, AV Skalny, AC Martins, AI Sinitskii… - Archives of …, 2022 - Springer
Ferroptosis is a recently discovered form of regulated cell death, implicated in multiple
pathologies. Given that the toxicity elicited by some metals is linked to alterations in iron …

The role of ferroptosis in lung cancer

S Wu, C Zhu, D Tang, QP Dou, J Shen, X Chen - Biomarker research, 2021 - Springer
Lung cancer is one of the most common cancers in the world. Although medical treatment
has made impressive progress in recent years, it is still one of the leading causes of cancer …

[HTML][HTML] Metal-fluorouracil networks with disruption of mitochondrion enhanced ferroptosis for synergistic immune activation

L Lei, Z Dong, L Xu, F Yang, B Yin, Y Wang, R Yue… - Theranostics, 2022 - ncbi.nlm.nih.gov
Rationale: Ferroptosis drugs inducing cancer immunogenic cell death (ICD) have shown the
potential of immunotherapy in vivo. However, the current ferroptosis drugs usually induce …

Zinc transporter ZIP7 is a novel determinant of ferroptosis

PH Chen, J Wu, Y Xu, CKC Ding, AA Mestre… - Cell death & …, 2021 - nature.com
Ferroptosis is a newly described form of regulated cell death triggered by oxidative stresses
and characterized by extensive lipid peroxidation and membrane damages. The name of …

Ferroptosis in non-small cell lung cancer: progression and therapeutic potential on it

J Zou, L Wang, H Tang, X Liu, F Peng… - International Journal of …, 2021 - mdpi.com
As a main subtype of lung cancer, the current situation of non-small cell lung cancer
(NSCLC) remains severe worldwide with a 19% survival rate at 5 years. As the conventional …

A promising future of ferroptosis in tumor therapy

H Wang, D Lin, Q Yu, Z Li, C Lenahan… - Frontiers in Cell and …, 2021 - frontiersin.org
Currently, mechanisms and therapeutic approaches have been thoroughly studied in
various prevalent malignant tumors, such as breast and lung cancer. However, there is …

Photothermal-enhanced inactivation of glutathione peroxidase for ferroptosis sensitized by an autophagy promotor

P An, Z Gao, K Sun, D Gu, H Wu, C You… - … applied materials & …, 2019 - ACS Publications
Until now, ferroptotic therapeutic strategies remain simple, although ferroptosis has aroused
extensive interest owing to its escape from the biocarriers of conventional therapeutic …

Advances of zinc signaling studies in prostate cancer

D Li, DB Stovall, W Wang, G Sui - International Journal of Molecular …, 2020 - mdpi.com
Prostate cancer (PCa) is one of the most common cancers and the second leading cause of
cancer-related death among men worldwide. Despite progresses in early diagnosis and …