Voltage-gated potassium (Kv) channels in the KCNQ (Kv7) family are essential features of a
broad range of excitable and non-excitable cell types and are found in organisms ranging …

Aloperine, a quinolizidine-type alkaloid, was first isolated from the seeds and leaves of
herbal plant, Sophora alopecuroides L. Empirically, Sophora alopecuroides L. is …

There are currently no drugs known to rescue the function of Kv1. 1 voltage-gated potassium
channels carrying loss-of-function sequence variants underlying the inherited movement …

Voltage-gated potassium (Kv) channels in the KCNQ subfamily serve essential roles in the
nervous system, heart, muscle and epithelia. Different heteromeric KCNQ complexes likely …

Since prehistory, human species have depended on plants for both food and medicine.
Even in countries with ready access to modern medicines, alternative treatments are still …

Many commonly consumed plants are used as folk medicines, often with unclear molecular
mechanisms. Recent studies uncovered the ubiquitous and influential KCNQ family of …

We identified six novel de novo human KCNQ5 variants in children with motor/language
delay, intellectual disability (ID), and/or epilepsy by whole exome sequencing. These …

Methods: We applied electrophysiology, myography, mass spectrometry and in silico
docking to determine effects and their underlying molecular mechanisms of tea and its …

The evergreen plant rosemary (Salvia rosmarinus) has been employed medicinally for
centuries as a memory aid, analgesic, spasmolytic, vasorelaxant and antihypertensive, with …

Indigenous peoples of the Americas are proficient in botanical medicine. KCNQ family
voltage-gated potassium (Kv) channels are sensitive to a variety of ligands, including plant …