Precision oncology continues to challenge the “one-size-fits-all” dogma. Under the precision
oncology banner, cancer patients are screened for molecular tumor alterations that predict …

Cancer immunotherapy has achieved remarkable success over the past decade by
modulating patients' own immune systems and unleashing pre-existing immunity. However …

Solid tumors generate a suppressive environment that imposes an overwhelming burden on
the immune system. Nutrient depletion, waste product accumulation, hypoxia, and pH …

The lungs are affected by illnesses including asthma, chronic obstructive pulmonary
disease, and infections such as influenza and SARS-CoV-2. Physiologically relevant models …

Several methods have been developed for generating 3D, in vitro, organ-on-chip models of
human vasculature to study vascular function, transport, and tissue engineering. However …

Immunotherapy remains more effective for hematologic tumors than for solid tumors. One of
the main challenges to immunotherapy of solid tumors is the immunosuppressive …

Nonalcoholic fatty liver disease (NAFLD) has emerged as a public health concern. To date,
the mechanism of NAFLD progression remains unclear, and pharmacological treatment …

Cancer is a leading cause of death across the world and continues to increase in incidence.
Despite years of research, multiple tumors (eg, glioblastoma, pancreatic cancer) still have …

The ever greater understanding of the composition and function of the gut microbiome has
provided new opportunities with respect to understanding and treating human disease …

Microphysiological systems are in vitro tissue and organ models that present unique
opportunities across different disciplines, such as biology, medicine, and engineering …