Magnetic Cellular Backpacks for Spatial Targeting, Imaging, and Immunotherapy

NB Day, CR Orear, AC Velazquez-Albino… - ACS Applied Bio …, 2023 - ACS Publications
Adoptive cell transfer (ACT) therapies are growing in popularity due to their ability to interact
with diseased tissues in a specific manner. Disc-shaped particles, or “backpacks”, that bind …

Bio-inspired drug delivery systems: A new attempt from bioinspiration to biomedical applications

L Ming, H Wu, Q Fan, Z Dong, J Huang, Z Xiao… - International Journal of …, 2024 - Elsevier
Natural organisms have evolved sophisticated and multiscale hierarchical structures over
time to enable survival. Currently, bionic design is revolutionizing drug delivery systems …

Neutrophils bearing adhesive polymer micropatches as a drug-free cancer immunotherapy

N Kumbhojkar, S Prakash, T Fukuta… - Nature Biomedical …, 2024 - nature.com
Tumour-associated neutrophils can exert antitumour effects but can also assume a pro-
tumoural phenotype in the immunosuppressive tumour microenvironment. Here we show …

Backpack-mediated anti-inflammatory macrophage cell therapy for the treatment of traumatic brain injury

N Kapate, R Liao, RL Sodemann, T Stinson… - PNAS …, 2024 - academic.oup.com
Traumatic brain injury (TBI) is a debilitating disease with no current therapies outside of
acute clinical management. While acute, controlled inflammation is important for debris …

Dendritic Cell Immune Modulation via Polyphenol Membrane Coatings

ME Janes, KS Park, AP Gottlieb, A Curreri… - … Applied Materials & …, 2024 - ACS Publications
Cellular hitchhiking is an emerging strategy for the in vivo control of adoptively transferred
immune cells. Hitchhiking approaches are primarily mediated by adhesion of nano and …

Polymer Micropatches as B-Cell Engagers

S Prakash, N Kumbhojkar, AP Gottlieb… - … Applied Materials & …, 2024 - ACS Publications
B cells, despite their several unique functionalities, remain largely untapped for use as an
adoptive cell therapy and are limited to in vitro use for antibody production. B cells can be …

Polymer Backpack‐Loaded Tissue Infiltrating Monocytes for Treating Cancer

N Kapate, M Dunne, AP Gottlieb… - Advanced …, 2024 - Wiley Online Library
Adoptive cell therapies are dramatically altering the treatment landscape of cancer.
However, treatment of solid tumors remains a major unmet need, in part due to limited …

The Power of Three: Nanomaterials for Natural Killer (NK) Cell Immunoengineering Maximize Their Potency if They Exploit Multireceptor Stimulation

H Dodd, N Guerra, IE Dunlop - Advanced Healthcare Materials, 2024 - Wiley Online Library
Many emerging cancer treatments are immunotherapies that modulate Natural Killer‐(NK) or
T cell activation, posing a challenge to develop immunoengineering nanomaterials that …

From Single‐Compartment Artificial Cells to Tissue‐Like Materials

IN Westensee, P de Dios Andres… - Advanced Materials …, 2024 - Wiley Online Library
Designing and assembling artificial cells (ACs) is a core direction in bottom‐up synthetic
biology. Here, the advancements in the past 3 years in engineering ACs with focus on …

Natural Killer Cell Mechanosensing in Solid Tumors

S Lightsey, B Sharma - Bioengineering, 2024 - mdpi.com
Natural killer (NK) cells, which are an exciting alternative cell source for cancer
immunotherapies, must sense and respond to their physical environment to traffic to and …