Magnetic Cellular Backpacks for Spatial Targeting, Imaging, and Immunotherapy
NB Day, CR Orear, AC Velazquez-Albino… - ACS Applied Bio …, 2023 - ACS Publications
Adoptive cell transfer (ACT) therapies are growing in popularity due to their ability to interact
with diseased tissues in a specific manner. Disc-shaped particles, or “backpacks”, that bind …
with diseased tissues in a specific manner. Disc-shaped particles, or “backpacks”, that bind …
Bio-inspired drug delivery systems: A new attempt from bioinspiration to biomedical applications
L Ming, H Wu, Q Fan, Z Dong, J Huang, Z Xiao… - International Journal of …, 2024 - Elsevier
Natural organisms have evolved sophisticated and multiscale hierarchical structures over
time to enable survival. Currently, bionic design is revolutionizing drug delivery systems …
time to enable survival. Currently, bionic design is revolutionizing drug delivery systems …
Neutrophils bearing adhesive polymer micropatches as a drug-free cancer immunotherapy
Tumour-associated neutrophils can exert antitumour effects but can also assume a pro-
tumoural phenotype in the immunosuppressive tumour microenvironment. Here we show …
tumoural phenotype in the immunosuppressive tumour microenvironment. Here we show …
Backpack-mediated anti-inflammatory macrophage cell therapy for the treatment of traumatic brain injury
Traumatic brain injury (TBI) is a debilitating disease with no current therapies outside of
acute clinical management. While acute, controlled inflammation is important for debris …
acute clinical management. While acute, controlled inflammation is important for debris …
Dendritic Cell Immune Modulation via Polyphenol Membrane Coatings
Cellular hitchhiking is an emerging strategy for the in vivo control of adoptively transferred
immune cells. Hitchhiking approaches are primarily mediated by adhesion of nano and …
immune cells. Hitchhiking approaches are primarily mediated by adhesion of nano and …
Polymer Micropatches as B-Cell Engagers
S Prakash, N Kumbhojkar, AP Gottlieb… - … Applied Materials & …, 2024 - ACS Publications
B cells, despite their several unique functionalities, remain largely untapped for use as an
adoptive cell therapy and are limited to in vitro use for antibody production. B cells can be …
adoptive cell therapy and are limited to in vitro use for antibody production. B cells can be …
Polymer Backpack‐Loaded Tissue Infiltrating Monocytes for Treating Cancer
Adoptive cell therapies are dramatically altering the treatment landscape of cancer.
However, treatment of solid tumors remains a major unmet need, in part due to limited …
However, treatment of solid tumors remains a major unmet need, in part due to limited …
The Power of Three: Nanomaterials for Natural Killer (NK) Cell Immunoengineering Maximize Their Potency if They Exploit Multireceptor Stimulation
Many emerging cancer treatments are immunotherapies that modulate Natural Killer‐(NK) or
T cell activation, posing a challenge to develop immunoengineering nanomaterials that …
T cell activation, posing a challenge to develop immunoengineering nanomaterials that …
From Single‐Compartment Artificial Cells to Tissue‐Like Materials
IN Westensee, P de Dios Andres… - Advanced Materials …, 2024 - Wiley Online Library
Designing and assembling artificial cells (ACs) is a core direction in bottom‐up synthetic
biology. Here, the advancements in the past 3 years in engineering ACs with focus on …
biology. Here, the advancements in the past 3 years in engineering ACs with focus on …
Natural Killer Cell Mechanosensing in Solid Tumors
S Lightsey, B Sharma - Bioengineering, 2024 - mdpi.com
Natural killer (NK) cells, which are an exciting alternative cell source for cancer
immunotherapies, must sense and respond to their physical environment to traffic to and …
immunotherapies, must sense and respond to their physical environment to traffic to and …