Pancreatic cancer is a deadly disease with high mortality due to difficulties in its early
diagnosis and metastasis. The tumor microenvironment induced by interactions between …

Although many drugs/treatments are now available for most diseases, too often, resistance
to these treatments impedes complete therapeutic success. Acquired resistance is a major …

Reliable detection of disseminated tumor cells and of the biodistribution of tumor-targeting
therapeutic antibodies within the entire body has long been needed to better understand …

Tumour cells migrate very early from primary sites to distant sites, and yet metastases often
take years to manifest themselves clinically or never even surface within a patient's lifetime …

Although substantial progress has been made over the past 40 years in treating patients
with cancer, effective therapies for those who are diagnosed with advanced metastatic …

Metastasis and relapse account for the great majority of cancer-related deaths. Most
metastatic lesions are micro metastases that have the capacity to remain in a non-dividing …

The characteristic desmoplastic stroma of pancreatic ductal adenocarcinoma (PDAC) is a
key contributor to its lethality. This stromal microenvironment is populated by cancer …

Simple Summary Pancreatic cancer is a highly malignant disease with treatment resistance
to standardized chemotherapies. In addition, only a small fraction of patients with pancreatic …

Pancreatic ductal adenocarcinoma (PDAC) is a hostile solid malignancy coupled with an
extremely high mortality rate. Metastatic disease is already found in most patients at the time …

Sex disparity in cancer is so far inadequately considered, and components of its basis are
rather unknown. We reveal that male versus female pancreatic cancer (PC) patients and …