BACKGROUND Many clinicians and patients believe that endometriosis-associated pain is
due to the lesions. Yet causality remains an enigma, because pain symptoms attributed to …

BACKGROUND Pain remains the cardinal symptom of endometriosis. However, to date, the
underlying mechanisms are still only poorly understood. Increasing evidence points towards …

Endometriosis (ENDO) is a disorder in which vascularized growths of endometrial tissue
occur outside the uterus. Its symptoms include reduced fertility and severe pelvic pain …

Endometriosis is a common gynaecological disease, defined as the presence of endometrial
tissue outside the uterus, causing pelvic pain and subfertility in∼ 10% of women of …

Provoked vestibulodynia, the most common form of vulvodynia (unexplained pain of the
vulva), is a prevalent, idiopathic pain disorder associated with a history of recurrent …

The female reproductive tract undergoes remarkable functional and structural changes
associated with cycling, conception and pregnancy, and it is likely advantageous to both …

Viscero-somatic referral and sensitization has been well documented clinically and widely
investigated, whereas viscero-visceral referral and sensitization (termed cross-organ …

Endometriosis is an incurable gynecological disorder characterized by debilitating pain and
the establishment of innervated endometriosis lesions outside the uterus. In a preclinical …

Pelvic pain associated with menstruation, ie, dysmenorrhea, is a chronic pelvic pain that not
only interferes with a woman's wellbeing for a large part of her life but also often co-occurs …

Central nervous system neurons process information converging from the uterus, colon, and
bladder, partly via the hypogastric nerve. This processing is influenced by the estrous cycle …