Mitochondrial DNA (mtDNA) is predominately uniparentally transmitted. This results in
organisms with a single type of mtDNA (homoplasmy), but two or more mtDNA haplotypes …

Metazoans exist only with a continuous and rich supply of chemical energy from oxidative
phosphorylation in mitochondria. The oxidative phosphorylation machinery that mediates …

Mitochondria, a nearly ubiquitous feature of eukaryotes, are derived from an ancient
symbiosis. Despite billions of years of cooperative coevolution—in what is arguably the most …

Natural selection acts on the phenotype. Therefore, many mistakenly expect to observe its
signatures only in the organism, while overlooking its impact on tissues, cells and …

Follicular microenvironment is paramount in the acquisition of oocyte competence, which is
dependent on two interconnected and interdependent processes: nuclear and cytoplasmic …

Numerous mitochondrial quality control mechanisms exist within cells, but none have been
shown to effectively assess and control the quality of mitochondrial DNA (mtDNA). One …

Inherited mutations in the mitochondrial (mt) DNA are a major cause of human disease, with
approximately 1 in 5000 people affected by one of the hundreds of identified pathogenic …

Abstract STUDY QUESTION Do mitochondrial DNA (mtDNA) copy number and
heteroplasmy in human embryos affect the ongoing pregnancy rate? SUMMARY ANSWER …

The developmental potential of early embryos is mainly dictated by the quality of the oocyte.
Here, we explore the utility of the maternal spindle transfer (MST) technique as a …

STUDY QUESTION Does germline selection (besides random genetic drift) play a role
during the transmission of heteroplasmic pathogenic mitochondrial DNA (mtDNA) mutations …