Significance: Pulmonary arterial hypertension (PAH) is a progressive disease of the lung
vasculature characterized by the proliferation of all vascular wall cell types, including …

Pulmonary arterial hypertension, or PAH, is a condition that is characterized by pulmonary
artery pressures above 20 mmHg (at rest). In the treatment of PAH, the pulmonary vascular …

COVID-19 is a severe disease in humans, as highlighted by the current global pandemic.
Several studies about the metabolome of COVID-19 patients have revealed metabolic …

Portopulmonary hypertension (PoPH) is a type of pulmonary vascular disease due to portal
hypertension that exhibits high morbidity and mortality. The mechanisms driving disease are …

Pulmonary arterial hypertension (PAH) is a progressive disease that significantly endangers
human health, where metabolism may drive pathogenesis: a shift from mitochondrial …

Metabolomic studies have demonstrated the existence of biological signatures in blood of
patients with arterial hypertension, but no study has hitherto reported the sexual dimorphism …

Background Circadian rhythms play a fundamental role in the progression of cardiovascular
events. Almost all cardiovascular diseases have a circadian misalignment usually …

Targeted direct injection/liquid chromatography coupled to tandem mass spectrometry-
based metabolomics was employed to identify metabolite alterations that could differentiate …

Introduction: Over time and despite optimal medical management of patients with pulmonary
hypertension (PH), the right ventricle (RV) function deteriorates from an adaptive to …

Background: Primary pulmonary hypertension (PPH) is a life-threatening disease associated
with increased mortality. The urea cycle pathway plays a major role in PPH severity and …