Deciphering chemical logic of fungal natural product biosynthesis through heterologous expression and genome mining

CY Chiang, M Ohashi, Y Tang - Natural product reports, 2023 - pubs.rsc.org
Covering: 2010 to 2022 Heterologous expression of natural product biosynthetic gene
clusters (BGCs) has become a widely used tool for genome mining of cryptic pathways …

[HTML][HTML] Developing fungal heterologous expression platforms to explore and improve the production of natural products from fungal biodiversity

X Meng, Y Fang, M Ding, Y Zhang, K Jia, Z Li… - Biotechnology …, 2022 - Elsevier
Natural products from fungi represent an important source of biologically active metabolites
notably for therapeutic agent development. Genome sequencing revealed that the number …

Navigating the fungal polyketide chemical space: from genes to molecules

YH Chooi, Y Tang - The Journal of organic chemistry, 2012 - ACS Publications
The iterative type I polyketide synthases (IPKSs) are central to the biosynthesis of an
enormously diverse array of natural products in fungi. These natural products, known as …

New insights into the formation of fungal aromatic polyketides

JM Crawford, CA Townsend - Nature Reviews Microbiology, 2010 - nature.com
Fungal aromatic polyketides constitute a large family of bioactive natural products and are
synthesized by the non-reducing group of iterative polyketide synthases (PKSs). Their …

The structural role of the carrier protein–active controller or passive carrier

J Crosby, MP Crump - Natural product reports, 2012 - pubs.rsc.org
Covering: 2007 to 2011. Previous review: Nat. Prod. Rep., 2007, 24, 750 Common to all
FASs, PKSs and NRPSs is a remarkable component, the acyl or peptidyl carrier protein …

Characterization of a silent azaphilone gene cluster from Aspergillus niger ATCC 1015 reveals a hydroxylation-mediated pyran-ring formation

AO Zabala, W Xu, YH Chooi, Y Tang - Chemistry & biology, 2012 - cell.com
Azaphilones are a class of fungal metabolites characterized by a highly oxygenated pyrano-
quinone bicyclic core and exhibiting a broad range of bioactivities. Although widespread …

Recent advances in the genome mining of Aspergillus secondary metabolites (covering 2012–2018)

J Romsdahl, CCC Wang - Medchemcomm, 2019 - pubs.rsc.org
Secondary metabolites (SMs) produced by filamentous fungi possess diverse bioactivities
that make them excellent drug candidates. Whole genome sequencing has revealed that …

LovG: the thioesterase required for dihydromonacolin L release and lovastatin nonaketide synthase turnover in lovastatin biosynthesis.

W Xu, YH Chooi, JW Choi, S Li… - Angewandte …, 2013 - search.ebscohost.com
The article discusses research on the development of a biocatalytic process for monacolin J
acid conversion into simvastatin acid. It acknowledges necessity of identifying a complete …

Biomimetic thioesters as probes for enzymatic assembly lines: synthesis, applications, and challenges

J Franke, C Hertweck - Cell Chemical Biology, 2016 - cell.com
Thioesters play essential roles in many biosynthetic pathways to fatty acids, esters,
polyketides, and non-ribosomal peptides. Coenzyme A (CoA) and related …

Saccharomyces cerevisiae as host for the recombinant production of polyketides and nonribosomal peptides

A Tippelt, M Nett - Microbial Cell Factories, 2021 - Springer
As a robust, fast growing and genetically tractable organism, the budding yeast
Saccharomyces cerevisiae is one of the most widely used hosts in biotechnology. Its …