The role of oxidative stress, antioxidants and vascular inflammation in cardiovascular disease (a review)

HN Siti, Y Kamisah, J Kamsiah - Vascular pharmacology, 2015 - Elsevier
The concept of mild chronic vascular inflammation as part of the pathophysiology of
cardiovascular disease, most importantly hypertension and atherosclerosis, has been well …

Reactive oxygen species: a key hallmark of cardiovascular disease

N Panth, KR Paudel, K Parajuli - Advances in medicine, 2016 - Wiley Online Library
Cardiovascular diseases (CVDs) have been the prime cause of mortality worldwide for
decades. However, the underlying mechanism of their pathogenesis is not fully clear yet. It …

Reactive oxygen species: Physiological and physiopathological effects on synaptic plasticity: Supplementary issue: Brain plasticity and repair

TF Beckhauser, J Francis-Oliveira… - Journal of …, 2016 - journals.sagepub.com
In the mammalian central nervous system, reactive oxygen species (ROS) generation is
counterbalanced by antioxidant defenses. When large amounts of ROS accumulate …

Novel therapeutics for the treatment of hypertension and its associated complications: peptide-and nonpeptide-based strategies

T Ghatage, SG Goyal, A Dhar, A Bhat - Hypertension Research, 2021 - nature.com
The renin-angiotensin-aldosterone system (RAAS) is responsible for maintaining blood
pressure and vascular tone. Modulation of the RAAS, therefore, interferes with essential …

Oxidative stress in chronic vascular disease: from prediction to prevention

F Santilli, D D'Ardes, G Davi - Vascular pharmacology, 2015 - Elsevier
This review article is intended to describe the strong relationship between oxidative stress
and vascular disease. Reactive oxygen species (ROS) play an important role in the …

Angiotensin-II-induced reactive oxygen species along the SFO-PVN-RVLM pathway: implications in neurogenic hypertension

VA Braga, IA Medeiros, TP Ribeiro… - Brazilian Journal of …, 2011 - SciELO Brasil
Neurogenic hypertension has been the subject of extensive research worldwide. This review
is based on the premise that some forms of neurogenic hypertension are caused in part by …

Coconut oil supplementation and physical exercise improves baroreflex sensitivity and oxidative stress in hypertensive rats

NFB Alves, SKP Porpino, MMO Monteiro… - Applied Physiology …, 2015 - cdnsciencepub.com
The hypothesis that oral supplementation with virgin coconut oil (Cocos nucifera L.) and
exercise training would improve impaired baroreflex sensitivity (BRS) and reduce oxidative …

Quercetin improves baroreflex sensitivity in spontaneously hypertensive rats

MMO Monteiro, MS França-Silva, NFB Alves… - Molecules, 2012 - mdpi.com
Quercetin is a well-known antioxidant. Here, we investigated the effects of treatment with
quercetin on mean arterial pressure (MAP), heart rate (HR) and baroreflex sensitivity (BRS) …

Cardioprotective Action of Ginkgo biloba Extract against Sustained β-Adrenergic Stimulation Occurs via Activation of M2/NO Pathway

TRR Mesquita, ICG De Jesus, JF Dos Santos… - Frontiers in …, 2017 - frontiersin.org
Ginkgo biloba is the most popular phytotherapic agent used worldwide for treatment of
several human disorders. However, the mechanisms involved in the protective actions of …

Low-level chronic lead exposure impairs neural control of blood pressure and heart rate in rats

MR Simoes, SC Preti, BF Azevedo, J Fiorim… - Cardiovascular …, 2017 - Springer
Lead (Pb) induces adverse effects when it chronically accumulates in the body, including
effects on the nervous and cardiovascular systems. Wistar rats were exposed to lead acetate …