Myelodysplastic syndromes: 2023 update on diagnosis, risk‐stratification, and management

G Garcia‐Manero - American journal of hematology, 2023 - Wiley Online Library
Disease overview The myelodysplastic syndromes (MDS) are a very heterogeneous group
of myeloid disorders characterized by peripheral blood cytopenias and increased risk of …

Treatment of MDS

U Platzbecker - Blood, The Journal of the American Society of …, 2019 - ashpublications.org
The heterogeneous nature of myelodysplastic syndromes (MDS) demands a complex and
personalized variety of therapeutic approaches. Among them, allogeneic hematopoietic …

[HTML][HTML] Luspatercept in patients with lower-risk myelodysplastic syndromes

P Fenaux, U Platzbecker, GJ Mufti… - … England Journal of …, 2020 - Mass Medical Soc
Background Patients with anemia and lower-risk myelodysplastic syndromes in whom
erythropoiesis-stimulating agent therapy is not effective generally become dependent on red …

Luspatercept for the treatment of anaemia in patients with lower-risk myelodysplastic syndromes (PACE-MDS): a multicentre, open-label phase 2 dose-finding study …

U Platzbecker, U Germing, KS Götze, P Kiewe… - The Lancet …, 2017 - thelancet.com
Background Myelodysplastic syndromes are characterised by ineffective erythropoiesis.
Luspatercept (ACE-536) is a novel fusion protein that blocks transforming growth factor beta …

Myelodysplastic syndromes, version 2.2017, NCCN clinical practice guidelines in oncology

PL Greenberg, RM Stone, A Al-Kali, SK Barta… - Journal of the National …, 2017 - jnccn.org
The myelodysplastic syndromes (MDS) comprise a heterogenous group of myeloid
disorders with a highly variable disease course. Diagnostic criteria to better stratify patients …

[HTML][HTML] Current challenges and unmet medical needs in myelodysplastic syndromes

U Platzbecker, AS Kubasch, C Homer-Bouthiette… - Leukemia, 2021 - nature.com
Myelodysplastic syndromes (MDS) represent a heterogeneous group of myeloid neoplasms
that are characterized by ineffective hematopoiesis, variable cytopenias, and a risk of …

Myelodysplastic syndromes: 2018 update on diagnosis, risk‐stratification and management

G Montalban‐Bravo… - American journal of …, 2018 - Wiley Online Library
Disease overview The myelodysplastic syndromes (MDS) are a very heterogeneous group
of myeloid disorders characterized by peripheral blood cytopenias and increased risk of …

Imetelstat achieves meaningful and durable transfusion independence in high transfusion–burden patients with lower-risk myelodysplastic syndromes in a phase II …

DP Steensma, P Fenaux, K Van Eygen… - Journal of Clinical …, 2021 - ascopubs.org
PURPOSE Patients with lower-risk (LR) myelodysplastic syndromes (MDS) who are RBC
transfusion dependent and have experienced relapse after or are refractory to erythropoiesis …

Randomized phase II study of azacitidine alone or in combination with lenalidomide or with vorinostat in higher-risk myelodysplastic syndromes and chronic …

MA Sekeres, M Othus, AF List, O Odenike… - Journal of Clinical …, 2017 - ascopubs.org
Purpose Azacitidine is standard, first-line therapy in higher-risk myelodysplastic syndromes
(MDS). Whether azacitidine-based combinations with lenalidomide or vorinostat produce …

Epidemiology of myelodysplastic syndromes: why characterizing the beast is a prerequisite to taming it

AM Zeidan, RM Shallis, R Wang, A Davidoff, X Ma - Blood reviews, 2019 - Elsevier
Myelodysplastic syndromes (MDS) consist of a heterogeneous group of myeloid neoplasms
characterized by inefficient hematopoiesis, variable cytopenias and a considerable risk of …