Acromegaly is a chronic systemic disease with many complications and is associated with
increased mortality when not adequately treated. Substantial advances in acromegaly …

Despite the high prevalence of performance-enhancing drug (PED) use, media attention has
focused almost entirely on PED use by elite athletes to illicitly gain a competitive advantage …

The British Society of Gastroenterology (BSG) and the Association of Coloproctology for
Great Britain and Ireland (ACPGBI) commissioned this update of the 2002 guidance. The …

This review focuses on the systemic complications of acromegaly. Mortality in this disease is
increased mostly because of cardiovascular and respiratory diseases, although currently …

Insulin and insulin-like growth factor (IGF) axes are major determinants of proliferation and
apoptosis and thus may influence carcinogenesis. In various animal models, modulation of …

BACKGROUND: Insulin-like growth factor-I (IGF-I) is a potent mitogen for normal and
neoplastic cells, whereas IGF-binding protein-3 (IGFBP-3) inhibits cell growth in many …

abstract Patients with acromegaly have a reduced life expectancy, with the accepted causes
for premature death being vascular and respiratory disease. Increased mortality from …

In February 1999, a workshop was held in Cortina, Italy to develop a consensus defining the
criteria for cure of acromegaly. The workshop was sponsored by the University of Brescia …

In the United States, colorectal cancer is the third leading cause of cancer deaths in each
sex and second for both sexes combined [1]. At current rates, approximately 6% of …

Interest in insulin-like growth factors (IGFs) and their effect on carcinogenesis has increased
recently because high serum concentrations of IGF1 are associated with an increased risk of …