The phylum Nucleocytoviricota includes the largest and most complex viruses known. These
“giant viruses” have a long evolutionary history that dates back to the early diversification of …

Our perception of viruses has been drastically evolving since the inception of the field of
virology over a century ago. In particular, the discovery of giant viruses from the …

Following the discovery of Acanthamoeba polyphaga mimivirus, diverse giant viruses have
been isolated. However, only a small fraction of these isolates have been completely …

Type II topoisomerases ubiquitously exist in cellular organisms, where they play an essential
role in resolving the topological problems of DNA. The viral type II topoisomerase encoded …

Type II topoisomerases are ubiquitous enzymes that play a pivotal role in modulating the
topological configuration of double-stranded DNA. These topoisomerases are required for …

The existence of LUCA in the distant past is the logical consequence of the binary
mechanism of cell division. The biosphere in which LUCA and contemporaries were living …

The dynamic processes operating on genomic DNA, such as gene expression and cellular
division, lead inexorably to topological challenges in the form of entanglements, catenanes …

Abstract Aminoacyl-tRNA synthetases (aaRSs), also known as tRNA ligases, are essential
enzymes in translation. Owing to their functional essentiality, these enzymes are conserved …

The African swine fever virus (ASFV) type II topoisomerase (Topo II), pP1192R, is the only
known Topo II expressed by mammalian viruses and is essential for ASFV replication in the …

Members of the phylum Nucleocytoviricota, also called “giant viruses” due to their large
physical dimensions and genome lengths, are a diverse group of dsDNA viruses that infect a …