Cl− channels reside both in the plasma membrane and in intracellular organelles. Their
functions range from ion homeostasis to cell volume regulation, transepithelial transport, and …

Ion channels are integral membrane proteins present on the plasma membrane as well as
intracellular membranes. In the human genome, there are more than 400 known genes …

Overlapping complementary DNA clones were isolated from epithelial cell libraries with a
genomic DNA segment containing a portion of the putative cystic fibrosis (CF) locus, which is …

An understanding of the basic defect in the inherited disorder cystic fibrosis requires cloning
of the cystic fibrosis gene and definition of its protein product. In the absence of direct …

Abstract THE ATP-binding cassette (ABC) superfamily of transport systems now includes
over thirty proteins that share extensive sequence similarity and domain organization …

We have previously demonstrated that the venom of the scorpion Leiurus quinquestriatus
blocks small-conductance Cl-channels, derived from epithelial cells, when applied to the …

A complementary DNA encoding a voltage-gated chloride channel from Torpedo marmorata
electric organ was cloned by expressing hybrid-depleted messenger RNA in Xenopus …

Luminal acidification is of pivotal importance for the physiology of the secretory and
endocytic pathways and its diverse trafficking events. Acidification by the proton-pumping V …

We have identified three different point mutations in the coding region of the cystic fibrosis
transmembrane conductance regulator (CFTR) gene. Each mutation segregates with the …

Chloride intracellular channel proteins (CLICs) are distinct from most ion channels in that
they have both soluble and integral membrane forms. CLICs are highly conserved in …