Objectives Precision medicine (PM) aims to improve patient outcomes by stratifying or
individualizing diagnosis and treatment decisions. Previous reviews found inconclusive …

Since the first polygenic risk score (PRS) in 2007, research in this area has progressed
significantly. The increasing number of SNPs that have been identified by large scale GWAS …

Developments in next-generation sequencing technologies have driven the clinical
application of diagnostic tests that interrogate the whole genome, which offer the chance to …

Purpose Methodological challenges have limited economic evaluations of genome
sequencing (GS) and exome sequencing (ES). Our objective was to develop conceptual …

Objectives Molecular biomarker tests can inform the clinical management of genomic
heterogeneous hematological malignancies, yet their availability in routine care largely …

Large organizations in the United States endure a 30%–50% failure to achieve profitability.
Senior executives' lack of strategies to ensure profitability diminish performance and …

Background Economic evaluations are widely used to predict the economic impact of new
treatment alternatives. Comprehensive economic reviews in the field of chronic lymphocytic …

Chronic lymphocytic leukemia (CLL) is the most common adult leukemia and is clinically
heterogeneous. Integration of oral targeted therapies (OTTs) in the management of CLL has …

Background Clinical indications for ibrutinib reimbursement in Australia should consider the
inclusion of patients with chronic lymphocytic leukemia (CLL) harboring prognostically …

Background Expert elicitation (EE) has been used across disciplines to estimate input
parameters for computational modeling research when information is sparse or conflictual …