Interleukin-18 (IL-18) is a potent pro-inflammatory cytokine involved in host defense against
infections and regulates the innate and acquired immune response. IL-18 is produced by …

Interleukin (IL)-18 was originally discovered as a factor that enhanced IFN-γ production from
anti-CD3-stimulated Th1 cells, especially in the presence of IL-12. Upon stimulation with Ag …

Cytokines are molecular messengers that allow the cells of the immune system to
communicate with one another to generate a coordinated, robust, but self-limited response …

The liver is an important immunological organ that remains sterile and tolerogenic in
homeostasis, despite continual exposure to non‐self food and microbial‐derived products …

TNF-related apoptosis-inducing ligand (TRAIL), a new member of TNF family, induces
apoptotic cell death of various tumor cells. We recently showed that TRAIL mediates perforin …

Abstract IL-13 and IL-4 have similar biological activities and are characteristic of cytokines
expressed by Th2 cells. In contrast, IL-12 and IL-18 have been shown to be strong cofactors …

The bacterium Burkholderia pseudomallei causes a life-threatening disease called
melioidosis. In vivo experiments in mice have identified that a rapid IFN-γ response is …

Innate immune response to microbes sometimes determines the nature of the following
specific response. Kupffer cells, a potent constituent of innate immunity, play a key role in …

IL-18 is a proinflammatory cytokine that plays an important role in NK cell activation and Th1
cell response. Recently IL-1R-related protein (IL-1Rrp) has been cloned as the receptor for …

We investigated the effects of IFN-γ-inducing factor (IL-18) in a ragweed (RW) mouse model
of allergic asthma. Administration of IL-18 in conjunction with allergic sensitization and …