ABSTRACT SQSTM1 (also known as p62) is a multifunctional stress-inducible scaffold
protein involved in diverse cellular processes. Its functions are tightly regulated through an …

Neurodegenerative diseases, characterized by a progressive loss of brain function, affect
the lives of millions of individuals worldwide. The complexity of the brain poses a challenge …

Aging-related, nonresolving inflammation in both the central nervous system (CNS) and
periphery predisposes individuals to the development of neurodegenerative disorders …

The N-end rule pathway is a proteolytic system involving the destabilization of N-terminal
amino acids, known as N-degrons, which are recognized by N-recognins. Dysregulation of …

Autophagic receptor p62 is a critical mediator of cell detoxification, stress response, and
metabolic programs and is commonly deregulated in human diseases. The diverse functions …

p62/Sequestosome‐1 (SQSTM1) is a selective autophagy receptor that recruits and delivers
intracellular substrates for bulk clearance through the autophagy lysosomal pathway …

N-degron pathways are proteolytic systems that target proteins bearing N-terminal (Nt)
degradation signals (degrons) called N-degrons. Nt-Arg of a protein is among Nt-residues …

Background and aims Central to the pathogenesis of nonalcoholic fatty liver disease
(NAFLD) is the accumulation of lipids in the liver and various fat tissues. We aimed to …

Ellagic acid (EA) is a natural phenol antioxidant in different fruits, vegetables, and nuts. As a
copper iron chelator from the tyrosinase enzyme's active site, EA was reported to inhibit …

Mutations in the TBK1 (TANK binding kinase 1) gene are causally linked to amyotrophic
lateral sclerosis (ALS) and frontotemporal dementia (FTD). TBK1 phosphorylates the cargo …