Conventional drug administration usually faces the problems of degradation and rapid
excretion when crossing many biological barriers, leading to only a small amount of drugs …

With growing interest in neurological diseases, treatment of neurodegenerative diseases
such as Alzheimer's disease is crucial. However, drug development for nervous system …

Abstract Functionalization of nanoscale (< 100 nm) particles at the cellular level is highly
specific and can be employed to develop efficient diagnostic and therapeutic procedures …

Many neurodegenerative diseases are identified but their causes and cure are far from
being well-known. The problem resides in the complexity of the neural tissue and its location …

The complex structure of the blood–brain barrier (BBB), which blocks nearly all large
biomolecules, hinders drug delivery to the brain and drug assessment, thus decelerating …

In vitro investigation of a glomerular filtration barrier (GFB) remains difficult because of the
inability to mimic its specialized structure, although various kidney diseases are …

There has been a significant increase in the prevalence of central nervous system (CNS)
disorders, resulting in a considerable decrease in the overall well-being for affected …

Researchers have placed engineered or natural tissues within microfluidic chips originating
the so-called organ-on-a-chip (OoC) devices. With this technology, organ models can be …

Background: Recently, the in vitro blood–brain barrier (BBB) models derived from human
pluripotent stem cells have been given extensive attention in therapeutics due to the …

[eng] Conventional 2D in vitro and animal models have been found inadequate to fully
uncover the intricate mechanisms happening in the brain and its diseases. Engineering …