Glioblastoma (GBM) tumor microenvironment (TME) is a highly heterogeneous and complex
system, which in addition to cancer cells, consists of various resident brain and immune cells …

Microglia are ramified cells that exhibit highly motile processes, which continuously survey
the brain parenchyma and react to any insult to the CNS homeostasis. Although microglia …

An optimally functional brain requires both excitatory and inhibitory inputs that are regulated
and balanced. A perturbation in the excitatory/inhibitory balance—as is the case in some …

Malignant gliomas are devastating tumours that frequently kill patients within 1 year of
diagnosis. The major obstacle to a cure is diffuse invasion, which enables tumours to …

Normal cells are hijacked by cancer cells forming together heterogeneous tumor masses
immersed in aberrant communication circuits that facilitate tumor growth and dissemination …

Brain tissue has a remarkable ability to accumulate glutamate. This ability is due to
glutamate transporter proteins present in the plasma membranes of both glial cells and …

System xc‐is an amino acid antiporter that typically mediates the exchange of extracellular l‐
cystine and intracellular l‐glutamate across the cellular plasma membrane. Studied in a …

The oxidative stress-inducible cystine/glutamate exchange system, system xc−, transports
one molecule of cystine, the oxidized form of cysteine, into cells and thereby releases one …

Epileptic seizures are a common and poorly understood comorbidity for individuals with
primary brain tumors. To investigate peritumoral seizure etiology, we implanted human …

Gliomas are a diverse group of primary central nervous system tumors that affect both
children and adults. Recent studies have revealed a dynamic cross talk that occurs between …