Female predisposition to TLR7-driven autoimmunity: gene dosage and the escape from X chromosome inactivation
Women develop stronger immune responses than men, with positive effects on the
resistance to viral or bacterial infections but magnifying also the susceptibility to autoimmune …
resistance to viral or bacterial infections but magnifying also the susceptibility to autoimmune …
[HTML][HTML] Estrogen receptor-dependent regulation of dendritic cell development and function
Autoimmunity, infectious diseases and cancer affect women and men differently. Because
they tend to develop more vigorous adaptive immune responses than men, women are less …
they tend to develop more vigorous adaptive immune responses than men, women are less …
[HTML][HTML] Type I interferon production of plasmacytoid dendritic cells under control
D Bencze, T Fekete, K Pázmándi - International journal of molecular …, 2021 - mdpi.com
One of the most powerful and multifaceted cytokines produced by immune cells are type I
interferons (IFNs), the basal secretion of which contributes to the maintenance of immune …
interferons (IFNs), the basal secretion of which contributes to the maintenance of immune …
[HTML][HTML] Sex differences in immunity: implications for the development of novel vaccines against emerging pathogens
A Fathi, MM Addo, C Dahlke - Frontiers in immunology, 2021 - frontiersin.org
Vaccines are one of the greatest public health achievements and have saved millions of
lives. They represent a key countermeasure to limit epidemics caused by emerging …
lives. They represent a key countermeasure to limit epidemics caused by emerging …
[HTML][HTML] Disease-associated plasmacytoid dendritic cells
Plasmacytoid dendritic cells (pDCs), also called natural interferon (IFN)-producing cells,
represent a specialized cell type within the innate immune system. pDCs are specialized in …
represent a specialized cell type within the innate immune system. pDCs are specialized in …
Human plasmacytoid dendritic cells elicit a Type I Interferon response by sensing DNA via the cGAS‐STING signaling pathway
Plasmacytoid dendritic cells (pDCs) are a major source of type I interferon (IFN) and are
important for host defense by sensing microbial DNA via TLR9. pDCs also play a critical role …
important for host defense by sensing microbial DNA via TLR9. pDCs also play a critical role …
Association of MicroRNA‐618 expression with altered frequency and activation of plasmacytoid dendritic cells in patients with systemic sclerosis
M Rossato, AJ Affandi, S Thordardottir… - Arthritis & …, 2017 - Wiley Online Library
Objective Plasmacytoid dendritic cells (PDCs) are a critical source of type I interferons (IFNs)
that can contribute to the onset and maintenance of autoimmunity. Molecular mechanisms …
that can contribute to the onset and maintenance of autoimmunity. Molecular mechanisms …
[HTML][HTML] Immunological processes driving IgE sensitisation and disease development in males and females
IgE sensitisation has increased significantly over the last decades and is a crucial factor in
the development of allergic diseases. IgE antibodies are produced by B cells through the …
the development of allergic diseases. IgE antibodies are produced by B cells through the …
[HTML][HTML] B cell-intrinsic role for IRF5 in TLR9/BCR-induced human B cell activation, proliferation, and plasmablast differentiation
Upon recognition of antigen, B cells undergo rapid proliferation followed by differentiation to
specialized antibody secreting cells (ASCs). During this transition, B cells are reliant upon a …
specialized antibody secreting cells (ASCs). During this transition, B cells are reliant upon a …
[HTML][HTML] The role of interferon regulatory factors in non-alcoholic fatty liver disease and non-alcoholic steatohepatitis
Non-alcoholic fatty liver disease (NAFLD) is becoming the most common chronic liver
disease with many metabolic comorbidities, such as obesity, diabetes, and cardiovascular …
disease with many metabolic comorbidities, such as obesity, diabetes, and cardiovascular …