Men's reproductive health exclusively depends on the appropriate maturation of certain
germ cells known as sperm. Certain illnesses, such as Klinefelter syndrome, cryptorchidism …

Aims This study aimed to explore the effect of epididymosomes on the proliferative efficiency
of spermatogonial stem cells (SSCs) in vitro and the resumption of spermatogenesis in the …

Background Effective culture systems for attachment, migration, proliferation, and
differentiation of spermatogonial stem cells (SSCs) can be a promising therapeutic modality …

Background The importance of spermatogonial stem cells (SSCs) in spermatogenesis is
crucial and intrinsic factors and extrinsic signals mediate fate decisions of SSCs. Among …

Mimicking the microenvironment of seminiferous tubules plays an indispensable role in
directing differentiation of stem cells toward germ cells in vitro. In this work, we fabricated …

Simple Summary The primary function of spermatogonial stem cells (SSC) in the testis is to
produce germ cells (GC) and sperm. This function may be recreated under laboratory …

Background Nano-fibrous scaffolds provide a three-dimensional matrix that guides sufficient
orientation of seeded cells similar to a natural niche. In this research, we designed a silk …

Engineering of 3D substrates with maximum similarity to seminiferous tubules would help to
produce functional sperm cells in vitro from stem cells. Here, we present a 3D electrospun …

Stem cell transplantation into seminiferous tubules of recipient testis could become a tool for
fertility restoration, genetic improvement, or conservation of endangered species …

Simple Summary The development of a biological system for gamete production may be a
ground-breaking strategy for the treatment of infertility in humans, improvement of genetic …