Tanshinone IIA: a review of its anticancer effects
Z Fang, M Zhang, J Liu, X Zhao, Y Zhang… - Frontiers in …, 2021 - frontiersin.org
Tanshinone IIA (Tan IIA) is a pharmacologically lipophilic active constituent isolated from the
roots and rhizomes of the Chinese medicinal herb Salvia miltiorrhiza Bunge (Danshen). Tan …
roots and rhizomes of the Chinese medicinal herb Salvia miltiorrhiza Bunge (Danshen). Tan …
Herbal nutraceuticals: safe and potent therapeutics to battle tumor hypoxia
Purpose Growing solid tumors mostly outstrip blood supply and become hypoxic (low
oxygen supply). To survive under this pathological milieu, tumors overexpress a potent …
oxygen supply). To survive under this pathological milieu, tumors overexpress a potent …
Tanshinone IIA inhibits β-catenin/VEGF-mediated angiogenesis by targeting TGF-β1 in normoxic and HIF-1α in hypoxic microenvironments in human colorectal …
H Sui, J Zhao, L Zhou, H Wen, W Deng, C Li, Q Ji, X Liu… - Cancer letters, 2017 - Elsevier
In a previous study, we demonstrated that Tanshinone IIA effectively inhibits CRC
angiogenesis in vivo, but the underlying mechanisms were not elucidated. In this report, we …
angiogenesis in vivo, but the underlying mechanisms were not elucidated. In this report, we …
Role of plant-derived active constituents in cancer treatment and their mechanisms of action
Despite significant technological advancements in conventional therapies, cancer remains
one of the main causes of death worldwide. Although substantial progress has been made …
one of the main causes of death worldwide. Although substantial progress has been made …
Tanshinone IIA: New perspective on the anti-tumor mechanism of A traditional natural medicine
W Zhang, C Liu, J Li, Y Lu, H Li, J Zhuang… - The American journal …, 2022 - World Scientific
The search for natural and efficacious antineoplastic drugs, with minimal toxicity and side
effects, is an important part of antitumor drug research and development. Tanshinone IIA is …
effects, is an important part of antitumor drug research and development. Tanshinone IIA is …
Danshen improves survival of patients with breast cancer and dihydroisotanshinone I induces ferroptosis and apoptosis of breast cancer cells
Danshen (salvia miltiorrhiza Bunge) is widely used in traditional Chinese medicine.
However, it is definite clinical effort and mechanism on breast cancer is unclear. In our study …
However, it is definite clinical effort and mechanism on breast cancer is unclear. In our study …
Vanillic acid suppresses HIF-1α expression via inhibition of mTOR/p70S6K/4E-BP1 and Raf/MEK/ERK pathways in human colon cancer HCT116 cells
J Gong, S Zhou, S Yang - International journal of molecular sciences, 2019 - mdpi.com
Hypoxia-inducible factor 1 (HIF-1) plays a pivotal role in tumor adaptation to
microenvironmental hypoxia, and it also exerts important roles in angiogenesis and tumor …
microenvironmental hypoxia, and it also exerts important roles in angiogenesis and tumor …
Recent nanotechnological interventions targeting PI3K/Akt/mTOR pathway: a focus on breast cancer
Breast cancer is the major cause of deaths in women worldwide. Detection and treatment of
breast cancer at earlier stages of the disease has shown encouraging results. Modern …
breast cancer at earlier stages of the disease has shown encouraging results. Modern …
The anticancer properties of tanshinones and the pharmacological effects of their active ingredients
L Fu, B Han, Y Zhou, J Ren, W Cao, G Patel… - Frontiers in …, 2020 - frontiersin.org
Cancer is a common malignant disease worldwide with an increasing mortality in recent
years. Salvia miltiorrhiza, a well-known traditional Chinese medicine, has been used for the …
years. Salvia miltiorrhiza, a well-known traditional Chinese medicine, has been used for the …
Advances on natural abietane, labdane and clerodane diterpenes as anti-cancer agents: Sources and mechanisms of action
Extensive research over the past decades has identified numerous phytochemicals that
could represent an important source of anti-cancer compounds. There is an immediate need …
could represent an important source of anti-cancer compounds. There is an immediate need …