[HTML][HTML] Disease-modifying therapeutic strategies in osteoarthritis: current status and future directions

Y Cho, S Jeong, H Kim, D Kang, J Lee… - … & molecular medicine, 2021 - nature.com
Osteoarthritis (OA) is the most common form of arthritis. It is characterized by progressive
destruction of articular cartilage and the development of chronic pain and constitutes a …

Pro-inflammatory cytokines: The link between obesity and osteoarthritis

T Wang, C He - Cytokine & growth factor reviews, 2018 - Elsevier
Osteoarthritis (OA), characterized by joint malfunction and chronic disability, is the most
common form of arthritis. Clinical and animal experiments reveal that age-related OA is …

Chondrocyte dedifferentiation and osteoarthritis (OA)

E Charlier, C Deroyer, F Ciregia, O Malaise… - Biochemical …, 2019 - Elsevier
Osteoarthritis (OA) is a degenerative joint disease characterized by progressive cartilage
degradation but also synovial membrane inflammation, osteophyte formation and …

[HTML][HTML] Cartilage tissue engineering: From proinflammatory and anti‑inflammatory cytokines to osteoarthritis treatments

S Liu, Z Deng, K Chen, S Jian… - Molecular …, 2022 - spandidos-publications.com
Osteoarthritis (OA), one of the most common joint diseases, is characterized by fibrosis,
rhagadia, ulcers and attrition of articular cartilage due to a number of factors. The etiology of …

The role of inflammatory and anti‐inflammatory cytokines in the pathogenesis of osteoarthritis

P Wojdasiewicz, ŁA Poniatowski… - Mediators of …, 2014 - Wiley Online Library
Osteoarthritis (OA) is the most common chronic disease of human joints. The basis of
pathologic changes involves all the tissues forming the joint; already, at an early stage, it has …

Apoptosis signaling pathways in osteoarthritis and possible protective role of melatonin

A Hosseinzadeh, SK Kamrava… - Journal of pineal …, 2016 - Wiley Online Library
Osteoarthritis (OA) is a degenerative joint disease characterized by progressive erosion of
articular cartilage. As chondrocytes are the only cell type forming the articular cartilage, their …

Mechanical stimulation of mesenchymal stem cells: Implications for cartilage tissue engineering

N Fahy, M Alini, MJ Stoddart - Journal of Orthopaedic Research …, 2018 - Wiley Online Library
Articular cartilage is a load‐bearing tissue playing a crucial mechanical role in diarthrodial
joints, facilitating joint articulation, and minimizing wear. The significance of biomechanical …

A current review of molecular mechanisms regarding osteoarthritis and pain

AS Lee, MB Ellman, D Yan, JS Kroin, BJ Cole… - Gene, 2013 - Elsevier
Osteoarthritis afflicts millions of individuals across the world resulting in impaired quality of
life and increased health costs. To understand this disease, physicians have been studying …

[HTML][HTML] Microvesicles from human adipose tissue-derived mesenchymal stem cells as a new protective strategy in osteoarthritic chondrocytes

M Tofiño-Vian, MI Guillén, MD Pérez del Caz… - Cellular Physiology and …, 2018 - karger.com
Background/Aims: Chronic inflammation contributes to cartilage degeneration during the
progression of osteoarthritis (OA). Adipose tissue-derived mesenchymal stem cells (AD …

Prostaglandin E2 synthesis and secretion: the role of PGE2 synthases

JY Park, MH Pillinger, SB Abramson - Clinical immunology, 2006 - Elsevier
Prostaglandin E2 (PGE2) is a principal mediator of inflammation in diseases such as
rheumatoid arthritis and osteoarthritis. Nonsteroidal anti-inflammatory medications (NSAIDs) …