Ubiquitin-specific protease 14 (USP14), a deubiquitinating enzyme (DUB), is associated
with proteasomes and exerts a dual function in regulating protein degradation. USP14 …

DNA double-strand breaks (DSBs) are accidental lesions generated by various endogenous
or exogenous stresses. DSBs are also genetically programmed events during the V (D) J …

In 2008, we published the first set of guidelines for standardizing research in autophagy.
Since then, this topic has received increasing attention, and many scientists have entered …

Objectives N6-methyladenosine (m6A) RNA methylation is implicated in the progression of
multiple cancers via influencing mRNA modification. YTHDF1 can act as an oncogene in …

CRISPR/Cas9 is an effective gene editing tool with broad applications for the prevention or
treatment of numerous diseases. It depends on CRISPR (clustered regularly interspaced …

TNFα is a key mediator of immune, chemotherapy and radiotherapy-induced cytotoxicity, but
several cancers, including head and neck squamous cell carcinomas (HNSCC), display …

MAPK/JNK signaling is pivotal in carcinogenesis. However, ubiquitin-mediated homeostasis
of JNK remains to be verified. Here, with results from RNA sequencing (RNA-seq) and …

The protooncoprotein N-Myc, which is overexpressed in approximately 25% of
neuroblastomas as the consequence of MYCN gene amplification, has long been postulated …

USP14 is a deubiquitinating enzyme involved in protein degradation by interacting with the
proteasome and removal of poly-ubiquitin chains on target proteins. USP14 can influence …

DNA repair is an important pathway for the protection of DNA molecules from destruction.
DNA damage can be produced by oxidative reactive nitrogen or oxygen species, irritation …