Over the years, researchers in drug discovery have taken advantage of the use of privileged
structures to design innovative hit/lead molecules. The α-ketoamide motif is found in many …

Since the first natural carbazole alkaloid, murrayanine, was isolated from Mwraya Spreng,
carbazole alkaloid derivatives have been widely concerned for their anti-tumor, anti-viral …

A series of sixteen β-carbolines, bearing chalcone moiety at C-1 position, were prepared
from easily accessible 1-acetyl-β-carboline and various aldehydes under basic conditions …

Abstract Novel topoisomerase II (Topo II) inhibitors have gained considerable interest for the
development of anticancer agents. In this study, a series of carbazole derivatives containing …

A series of twenty four 2-(carbazol-3-yl)-2-oxoacetamide analogues were synthesized,
characterized and evaluated for their pancreatic lipase (PL) inhibitory activity. Porcine PL …

The carbazole skeleton, a key structural motif occurring naturally or chemically synthesized,
showed various biological activities. Molecular hybridization based on the combination of …

A series of new pyranocarbazole derivatives were synthesized via semi-synthetic
modification of koenimbine (1a) and koenidine (1b) isolated from the leaves of Murraya …

Many drugs used to treat non-infectious diseases have also shown excellent antibacterial
activity or the ability to enhance the action of antibiotics. The aim of this study was to …

In recent years, indolylglyoxylamide-based derivatives have received much attention due to
their application in drug design and discovery, leading to the development of a wide array of …

A series of novel β-carbolinium bromides has been synthesized from easily accessible β-
carbolines and 1-aryl-2-bromoethanones. The newly synthesized compounds were …