Sequential transarterial chemoembolisation and stereotactic body radiotherapy followed by immunotherapy as conversion therapy for patients with locally advanced …

CL Chiang, KWH Chiu, KSK Chan, FAS Lee… - The Lancet …, 2023 - thelancet.com
Background The synergy between locoregional therapies and immune checkpoint inhibitors
has not been investigated as conversion therapy for unresectable hepatocellular carcinoma …

[HTML][HTML] Combined radiotherapy and immune checkpoint inhibition for the treatment of advanced hepatocellular carcinoma

AH Shannon, A Manne, DA Diaz Pardo… - Frontiers in …, 2023 - frontiersin.org
Hepatocellular Carcinoma (HCC) is one of the most common cancers and a leading cause
of cancer related death worldwide. Until recently, systemic therapy for advanced HCC …

[HTML][HTML] Radiation and immune checkpoint inhibitors: combination therapy for treatment of hepatocellular carcinoma

P Chami, Y Diab, DN Khalil, H Azhari… - International Journal of …, 2023 - mdpi.com
The liver tumor immune microenvironment has been thought to possess a critical role in the
development and progression of hepatocellular carcinoma (HCC). Despite the approval of …

[HTML][HTML] Survival outcome analysis of stereotactic body radiotherapy and immunotherapy (SBRT-IO) versus SBRT-alone in unresectable hepatocellular carcinoma

CL Chiang, FAS Lee, KSK Chan, VWY Lee, KWH Chiu… - Liver Cancer, 2024 - karger.com
Introduction: While combination of stereotactic body radiotherapy (SBRT) and
immunotherapy are promising, their efficacy and safety have not been compared with SBRT …

[HTML][HTML] Association of multi-phasic MR-based radiomic and dosimetric features with treatment response in unresectable hepatocellular carcinoma patients following …

LM Ho, SK Lam, J Zhang, CL Chiang, ACY Chan, J Cai - Cancers, 2023 - mdpi.com
Simple Summary Hepatocellular carcinoma (HCC) is one of the most prevalent and
devastating malignancies worldwide. An ongoing phase-II clinical trial assesses the efficacy …

[HTML][HTML] Hepatocellular carcinoma: Advances in systemic therapies

TKH Wu, RWH Hui, LY Mak, J Fung, WK Seto… - …, 2024 - ncbi.nlm.nih.gov
Advanced hepatocellular carcinoma (HCC) is traditionally associated with limited treatment
options and a poor prognosis. Sorafenib, a multiple tyrosine kinase inhibitor, was introduced …

Prognostic Value of a CT Radiomics‐Based Nomogram for the Overall Survival of Patients with Nonmetastatic BCLC Stage C Hepatocellular Carcinoma after …

L Wang, D Yan, L Shen, Y Xie, S Yan - Journal of Oncology, 2023 - Wiley Online Library
Purpose. This study aimed to investigatie the feasibility of pretherapeutic CT radiomics‐
based nomograms to predict the overall survival (OS) of patients with nondistant metastatic …

[HTML][HTML] Impact of immune tolerance mechanisms on the efficacy of immunotherapy in primary and secondary liver cancers

K Sankar, AN Pearson, T Worlikar… - Translational …, 2023 - ncbi.nlm.nih.gov
The liver is a functionally unique organ with an immunosuppressive microenvironment. The
liver is the sixth most common site of primary cancer in humans and is a frequent site of …

[HTML][HTML] Radiotherapy plus anti-PD1 versus radiotherapy for hepatic toxicity in patients with hepatocellular carcinoma

RJ Zhang, HM Zhou, HY Lu, HP Yu, WZ Tang… - Radiation …, 2023 - Springer
Purpose In this study, we aimed to compare the radiation-induced hepatic toxicity (RIHT)
outcomes of radiotherapy (RT) plus antibodies against programmed cell death protein 1 …

[HTML][HTML] The role of stereotactic body radiotherapy in hepatocellular carcinoma: Guidelines and evidences

Y Hu, C Zhao, R Ji, W Chen, Q Shen, CL Chiang… - Journal of the National …, 2022 - Elsevier
Hepatocellular carcinoma (HCC) is a common malignancy with high mortality rates. While
surgery can be curative in early-stage disease, 80% of patients cannot undergo surgical …