Quorum sensing is a cell-cell communication process in which bacteria use the production
and detection of extracellular chemicals called autoinducers to monitor cell population …

Chemotaxis allows bacteria to follow gradients of nutrients and other environmental stimuli.
The bacterium Escherichia coli performs chemotaxis via a run-and-tumble strategy in which …

Praise for the first edition:… superb, beautifully written and organized work that takes an
engineering approach to systems biology. Alon provides nicely written appendices to …

Physical Biology of the Cell is a textbook for a first course in physical biology or biophysics
for undergraduate or graduate students. It maps the huge and complex landscape of cell …

In their natural environment, cells need to extract useful information from complex temporal
signals that vary over a wide range of intensities and time scales. Here, we study how such …

Bacteria sense their environment using receptors of the histidine sensor kinase family, but
how kinase activity is regulated by ligand binding is not well understood. Autoinducer-2 (AI …

We studied the response of swimming Escherichia coli (E. coli) bacteria in a comprehensive
set of well-controlled chemical concentration gradients using a newly developed microfluidic …

The Escherichia coli chemotaxis‐signaling pathway computes time derivatives of
chemoeffector concentrations. This network features modules for signal …

Regular environmental conditions allow for the evolution of specifically adapted responses,
whereas complex environments usually lead to conflicting requirements upon the …

Many types of cells are able to accurately sense shallow gradients of chemicals across their
diameters, allowing the cells to move toward or away from chemical sources. This …