Organoids

Z Zhao, X Chen, AM Dowbaj, A Sljukic… - Nature Reviews …, 2022 - nature.com
Organoids are simple tissue-engineered cell-based in vitro models that recapitulate many
aspects of the complex structure and function of the corresponding in vivo tissue. They can …

Human organoids in basic research and clinical applications

XY Tang, S Wu, D Wang, C Chu, Y Hong… - Signal transduction and …, 2022 - nature.com
Organoids are three-dimensional (3D) miniature structures cultured in vitro produced from
either human pluripotent stem cells (hPSCs) or adult stem cells (AdSCs) derived from …

High cell density and high-resolution 3D bioprinting for fabricating vascularized tissues

S You, Y Xiang, HH Hwang, DB Berry… - Science …, 2023 - science.org
Three-dimensional (3D) bioprinting techniques have emerged as the most popular methods
to fabricate 3D-engineered tissues; however, there are challenges in simultaneously …

Engineering organoids

M Hofer, MP Lutolf - Nature Reviews Materials, 2021 - nature.com
Organoids are in vitro miniaturized and simplified model systems of organs that have gained
enormous interest for modelling tissue development and disease, and for personalized …

Towards organoid culture without Matrigel

MT Kozlowski, CJ Crook, HT Ku - Communications biology, 2021 - nature.com
Organoids—cellular aggregates derived from stem or progenitor cells that recapitulate organ
function in miniature—are of growing interest in developmental biology and medicine …

Vascular endothelial cell development and diversity

E Trimm, K Red-Horse - Nature Reviews Cardiology, 2023 - nature.com
Vascular endothelial cells form the inner layer of blood vessels where they have a key role
in the development and maintenance of the functional circulatory system and provide …

Engineering the multiscale complexity of vascular networks

C O'Connor, E Brady, Y Zheng, E Moore… - Nature Reviews …, 2022 - nature.com
The survival of vertebrate organisms depends on highly regulated delivery of oxygen and
nutrients through vascular networks that pervade nearly all tissues in the body …

Human organoids: model systems for human biology and medicine

J Kim, BK Koo, JA Knoblich - Nature Reviews Molecular Cell Biology, 2020 - nature.com
The historical reliance of biological research on the use of animal models has sometimes
made it challenging to address questions that are specific to the understanding of human …

Generation of vascularized brain organoids to study neurovascular interactions

XY Sun, XC Ju, Y Li, PM Zeng, J Wu, YY Zhou… - elife, 2022 - elifesciences.org
Brain organoids have been used to recapitulate the processes of brain development and
related diseases. However, the lack of vasculatures, which regulate neurogenesis and brain …

Human organoid models to study SARS-CoV-2 infection

Y Han, L Yang, LA Lacko, S Chen - Nature Methods, 2022 - nature.com
Abstract Coronavirus disease 2019 (COVID-19) caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) is one of the deadliest pandemics in history. SARS …