Side chain-fluorinated amino acids are useful tools in medicinal chemistry and protein
science. In this review, we outline some general strategies for incorporating fluorine atom (s) …

Mycobacterium tuberculosis, the causative agent of tuberculosis (TB), is the most significant
cause of death from a single infectious agent worldwide. Antibiotic-resistant strains of M …

Indole propionic acid (IPA), produced by the gut microbiota, is active against Mycobacterium
tuberculosis in vitro and in vivo. However, its mechanism of action is unknown. IPA is the …

Tuberculosis caused by the bacterium, Mycobacterium tuberculosis (Mtb), continues to
remain one of the most devastating infectious diseases afflicting humans. Although there are …

In Mycobacterium tuberculosis, proline dehydrogenase (PruB) and∆ 1-pyrroline-5-
carboxylate (P5C) dehydrogenase (PruA) are monofunctional enzymes that catalyze proline …

Indolmycin (IND) is a microbial natural product that selectively inhibits bacterial tryptophanyl-
tRNA synthetase (TrpRS). The tryptophan biosynthesis pathway was recently shown to be …

Background l-Tryptophan (l-Trp), an essential amino acid, is the only amino acid whose
level is regulated specifically by immune signals. Most proportions of Trp are catabolized via …

The biosynthetic pathways of amino acids are attractive targets for drug development
against pathogens with an intracellular behavior like M. tuberculosis (Mtb). Indeed, while in …

Tryptophan biosynthesis represents an important potential drug target for new anti-TB drugs.
We identified a series of indole-4-carboxamides with potent antitubercular activity. In vitro …

Enzyme promiscuity has important implications in the field of biocatalysis. In some cases,
structural analogues of simple metabolic building blocks can be processed through entire …